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These results expand our understanding of human adaptation to a ketogenic diet combined with exercise. In conjunction with weight loss, we observed altered skeletal muscle mitochondrial function and efficiency, an effect that may contribute to the therapeutic use of ketogenic diets in various clinical conditions, especially those associated with insulin resistance...
Carbohydrate-restricted diets are a practical and sustainable lifestyle approach to manage conditions closely associated with insulin resistance, including metabolic syndrome and type 2 diabetes...
Given the involvement of both insulin resistance and mitochondrial impairment in a wide variety of degenerative diseases, if enhancement of mitochondrial function is a mechanism through which ketogenic diets improve insulin sensitivity, this would imply potential for major improvements in public health.
Carbohydrate-restricted diets are a practical and sustainable lifestyle approach to manage conditions closely associated with insulin resistance, including metabolic syndrome and type 2 diabetes...
Given the involvement of both insulin resistance and mitochondrial impairment in a wide variety of degenerative diseases, if enhancement of mitochondrial function is a mechanism through which ketogenic diets improve insulin sensitivity, this would imply potential for major improvements in public health.