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Serotine Syndrome

sportsfan

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Serotonin syndrome occurs when you take medications that cause high levels of the chemical serotonin to accumulate in your body.

Serotonin is a chemical your body produces that's needed for your nerve cells and brain to function. But too much serotonin causes signs and symptoms that can range from mild (shivering and diarrhea) to severe (muscle rigidity, fever and seizures). Severe serotonin syndrome can cause death if not treated.

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Serotonin syndrome can occur when you increase the dose of certain medications or add a new drug to your regimen. Some illegal drugs and dietary supplements also are associated with serotonin syndrome.

Milder forms of serotonin syndrome may go away within a day of stopping the medications that cause symptoms and, sometimes, after taking drugs that block serotonin.


Symptoms
Serotonin syndrome symptoms usually occur within several hours of taking a new drug or increasing the dose of a drug you're already taking.

Signs and symptoms include:

  • Agitation or restlessness
  • Confusion
  • Rapid heart rate and high blood pressure
  • Dilated pupils
  • Loss of muscle coordination or twitching muscles
  • Muscle rigidity
  • Heavy sweating
  • Diarrhea
  • Headache
  • Shivering
  • Goose bumps
Severe serotonin syndrome can be life-threatening. Signs include:

  • High fever
  • Seizures
  • Irregular heartbeat
  • Unconsciousness
When to see a doctor
If you suspect you might have serotonin syndrome after starting a new drug or increasing the dose of a drug you're already taking, call your doctor right away or go to the emergency room. If you have severe or rapidly worsening symptoms, seek emergency treatment immediately.

Request an Appointment at Mayo Clinic
Causes
Excessive accumulation of serotonin in your body creates the symptoms of serotonin syndrome.

Under normal circumstances, nerve cells in your brain and spinal cord produce serotonin that helps regulate your attention, behavior and body temperature.

Other nerve cells in your body, primarily in your intestines, also produce serotonin. Serotonin plays a role in regulating your digestive process, blood flow and breathing.

Although it's possible that taking just one drug that increases serotonin levels can cause serotonin syndrome in susceptible individuals, this condition occurs most often when you combine certain medications.

For example, serotonin syndrome may occur if you take an antidepressant with a migraine medication. It may also occur if you take an antidepressant with an opioid pain medication.

Another cause of serotonin syndrome is intentional overdose of antidepressant medications.

A number of over-the-counter and prescription drugs may be associated with serotonin syndrome, especially antidepressants. Illicit drugs and dietary supplements also may be associated with the condition.

The drugs and supplements that could potentially cause serotonin syndrome include:

  • Selective serotonin reuptake inhibitors (SSRIs), antidepressants such as citalopram (Celexa), fluoxetine (Prozac, Sarafem), fluvoxamine, paroxetine (Paxil, Pexeva, Brisdelle) and sertraline (Zoloft)
  • Serotonin and norepinephrine reuptake inhibitors (SNRIs), antidepressants such as duloxetine (Cymbalta, Drizalma Sprinkle) and venlafaxine (Effexor XR)
  • Bupropion (Zyban, Wellbutrin SR, Wellbutrin XL), an antidepressant and tobacco-addiction medication
  • Tricyclic antidepressants, such as amitriptyline and nortriptyline (Pamelor)
  • Monoamine oxidase inhibitors (MAOIs), antidepressants such as isocarboxazid (Marplan) and phenelzine (Nardil)
  • Anti-migraine medications, such as carbamazepine (Tegretol, Carbatrol, others), valproic acid (Depakene) and triptans, which include almotriptan, naratriptan (Amerge) and sumatriptan (Imitrex, Tosymra, others)
  • Pain medications, such as opioid pain medications including codeine, fentanyl (Duragesic, Abstral, others), hydrocodone (Hysingla ER, Zohydro ER), meperidine (Demerol), oxycodone (Oxycontin, Roxicodone, others) and tramadol (Ultram, ConZip)
  • Lithium (Lithobid), a mood stabilizer
  • Illicit drugs, including LSD, ecstasy, cocaine and amphetamines
  • Herbal supplements, including St. John's wort, ginseng and nutmeg
  • Over-the-counter cough and cold medications containing dextromethorphan (Delsym)
  • Anti-nausea medications such as granisetron (Sancuso, Sustol), metoclopramide (Reglan), droperidol (Inapsine) and ondansetron (Zofran, Zuplenz)
  • Linezolid (Zyvox), an antibiotic
  • Ritonavir (Norvir), an anti-retroviral medication used to treat HIV
Risk factors
Some people are more susceptible to the drugs and supplements that cause serotonin syndrome than are others, but the condition can occur in anyone.

You're at increased risk of serotonin syndrome if:

  • You recently started taking or increased the dose of a medication known to increase serotonin levels
  • You take more than one drug known to increase serotonin levels
  • You take herbal supplements known to increase serotonin levels
  • You use an illicit drug known to increase serotonin levels
Complications
Serotonin syndrome generally doesn't cause any problems once serotonin levels are back to normal.

If left untreated, severe serotonin syndrome can lead to unconsciousness and death.

Prevention
Taking more than one serotonin-related medication or increasing your dose of a serotonin-related medication increases your risk of serotonin syndrome.

Be sure to talk to your doctor if you or a family member has experienced symptoms after taking a medication.

Also talk to your doctor about possible risks. Don't stop taking any such medications on your own. If your doctor prescribes a new medication, make sure he or she knows about all the other medications you're taking, especially if you receive prescriptions from more than one doctor.

If you and your doctor decide the benefits of combining certain serotonin-level-affecting drugs outweigh the risks, be alert to the possibility of serotonin syndrome.

Before the mark of the beast stuff started I had serotonin syndrome and it makes me wonder if serotonin syndrome is why I think I have it I have every symptom and it is why It causes confusion buspar so it makes sense why I got confused by the yellow cross.

So the evil dream was triggered by serotonin syndrome the blasphemy of the Holy Spirit but it may not have been Satan if it is serotonin this ikeep you swsy from Jesus.

Jesus promises to never leave or forsake and that no power of hell can seperate from the Love of God. If the dream hallucination changed my salvation the Bible wouldnt be real but it is real.
 
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i suffered from serotonin syndrome, taking 5-htp and anti depressants. The doctor told me that a small dosage of anti-depressants wasn't going to put me at risk taking 5-htp as well but it did.

i was very sick. With violent shaking and high fevers. i have never been so violently ill in such a small amount of time. i stopped taking the 5-htp and recovered two or three days later and have had no further troubles.

Best watch out for serotonin syndrome it is not pleasant.
 
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i suffered from serotonin syndrome, taking 5-htp and anti depressants. The doctor told me that a small dosage of anti-depressants wasn't going to put me at risk taking 5-htp as well but it did.

i was very sick. With violent shaking and high fevers. i have never been so violently ill in such a small amount of time. i stopped taking the 5-htp and recovered two or three days later and have had no further troubles.

Best watch out for serotonin syndrome it is not pleasant.

Yes it is not a fun condition but it is comforting that it caused the yellow cross to appear making me think I am the Antichrist False Prophet when I asked Jesus in my heart and Jesus promised to never leave or forsake and no power of hell can seperate from Jesus. Jesus not mad about yellow cross. The Yellow Cross occured from to much serotonin in my brain.
 
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Jeshu

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Yes it is not a fun condition but it is comforting that it caused the yellow cross to appear making me think I am the Antichrist False Prophet when I asked Jesus in my heart and Jesus promised to never leave or forsake and no power of hell can seperate from Jesus. Jesus not mad about yellow cross. The Yellow Cross occured from to much serotonin in my brain.

How horrible that you experienced hallucinations as part of serotonin Syndrome, that didn't happen with me. i just became really sick and shook so severely that my whole body hurt for three days afterwards.

i do know about hallucinations though. The devil told me that i was the son of lawlessness and that Jesus would cut me down and send me to hell. i believed him for years hurting hell in my depressive mood. It wasn't until Jesus showed me that satan is the son of lawlessness and i was His son because i believed in Jesus that i managed to overcome thinking i was the son of lawlessness and an anti-Christ.

Now i know i'm a child of God, because of Jesus, i'm totally secure in my identity now and i hope and pray Jesus will work that in your heart as well. To believe the truth of God sets you free, to believe lies enslaves to guilt, shame and fear. Be strong brother Jesus loves you to forget about your hallucination and not give it any value any more, apart of a lesson well learned. the devil uses our psychotic times to spin lies about God, ourselves and others, it is best not to believe anything the accuser in our minds says but trust in the forgiving blood of our Saviour. He will never let us go or let satan snatch us out of Father's hand.

Be of good courage.
 
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How horrible that you experienced hallucinations as part of serotonin Syndrome, that didn't happen with me. i just became really sick and shook so severely that my whole body hurt for three days afterwards.

i do know about hallucinations though. The devil told me that i was the son of lawlessness and that Jesus would cut me down and send me to hell. i believed him for years hurting hell in my depressive mood. It wasn't until Jesus showed me that satan is the son of lawlessness and i was His son because i believed in Jesus that i managed to overcome thinking i was the son of lawlessness and an anti-Christ.

Now i know i'm a child of God, because of Jesus, i'm totally secure in my identity now and i hope and pray Jesus will work that in your heart as well. To believe the truth of God sets you free, to believe lies enslaves to guilt, shame and fear. Be strong brother Jesus loves you to forget about your hallucination and not give it any value any more, apart of a lesson well learned. the devil uses our psychotic times to spin lies about God, ourselves and others, it is best not to believe anything the accuser in our minds says but trust in the forgiving blood of our Saviour. He will never let us go or let satan snatch us out of Father's hand.

Be of good courage.

Exactly the yellow cross is a dream from serotonin syndrome Satan can't steal salvation. I feel more relaxed now knowing it is medical but I still have to ask my mom for reassurance but she provides it for me and the Holy Bible would warn about a yellow cross that takes salvation if it was real so it is clearly mental illness.
 
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