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Discussion and Debate
Discussion and Debate
Physical & Life Sciences
Creation & Evolution
Is it a hoax?
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<blockquote data-quote="mark kennedy" data-source="post: 71763626" data-attributes="member: 29337"><p>Brain related genes aren't highly conserved; I feel like we have had this discussion before. HOX genes, genes that signal structures to develop in certain spots, are highly conserved and thus present in very similar forms even in organisms not closely related, such as between fruit flies and humans. But, as for brain genes in general, in humans, they are some of the most frequently mutating genes. The overall super high mutation rate in our species could be to blame for our high rate of miscarriage.</p></blockquote><p></p><p>I see nothing good coming from mutations in the HOX genes and a Pandora's box of deleterious effects:</p><p></p><ul style="margin-left: 20px"> <li data-xf-list-type="ul">HOXA1 Bosley–Salih–Alorainy syndrome (BSAS) Athabascan brainstem dysgenesis syndrome (ABDS)</li> <li data-xf-list-type="ul">HOXA2-associated autosomal recessive microtia</li> <li data-xf-list-type="ul">ARX (the aristaless-related homeobox gene) is a transcription factor that participates in the development of GABAergic and cholinergic neurons in the forebrain. Many ARX mutations have been identified in X-linked lissencephaly and mental retardation with epilepsy (Hum Mol Genet. 2009 Oct 1)</li> </ul><p></p><p></p><p>So it makes little sense that the chimpanzee at one time was bipedal but it makes perfect sense that highly conserved brain related genes can undergo massive overhauls and de novo creation?</p><p>[/QUOTE]</p>
[QUOTE="mark kennedy, post: 71763626, member: 29337"] Brain related genes aren't highly conserved; I feel like we have had this discussion before. HOX genes, genes that signal structures to develop in certain spots, are highly conserved and thus present in very similar forms even in organisms not closely related, such as between fruit flies and humans. But, as for brain genes in general, in humans, they are some of the most frequently mutating genes. The overall super high mutation rate in our species could be to blame for our high rate of miscarriage.[/quote] I see nothing good coming from mutations in the HOX genes and a Pandora's box of deleterious effects: [INDENT][LIST] [*]HOXA1 Bosley–Salih–Alorainy syndrome (BSAS) Athabascan brainstem dysgenesis syndrome (ABDS) [*]HOXA2-associated autosomal recessive microtia [*]ARX (the aristaless-related homeobox gene) is a transcription factor that participates in the development of GABAergic and cholinergic neurons in the forebrain. Many ARX mutations have been identified in X-linked lissencephaly and mental retardation with epilepsy (Hum Mol Genet. 2009 Oct 1) [/LIST][/INDENT] So it makes little sense that the chimpanzee at one time was bipedal but it makes perfect sense that highly conserved brain related genes can undergo massive overhauls and de novo creation? [/QUOTE]
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