I'll doubtless draw flames, but one must say what they believe. This is not meant to be inflammatory - I am simply very traditional.
In my emotions I'm of mixed feelings. Condaleeza Rice is an absolutely awesome national security advisor, and I was very impressed by Maggie Thatcher during her work. I know that Deborah was appointed by God when the men were not stepping up to the plate. However, knowing my mom and her moods I'd be concerned if she were to become president.
I really would like to see the men to continue to step up to the plate. My principles based on scripture believe that they have the responsibility to lead and lead well. There is the creation mandate (Gen 3:16), and Isaiah in prophecy talks about the women and children ruling a country (below). If a godly woman were the choice in a major party above an immoral man, though, I would quite possibly vote for her, though I might vote for a minor party. It would be a struggle of conscience.
I know that most people differ, and many women put men to shame by their capabilities, but this is what I am conscience bound to.
Isaiah 3:
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4 "I will give children to be their princes,
And babes shall rule over them.
5 The people will be oppressed,
Every one by another and every one by his neighbor;
The child will be insolent toward the elder,
And the base toward the honorable."
....
12 As for My people, children are their oppressors,
And women rule over them.
O My people! Those who lead you cause you to err,
And destroy the way of your paths."
Pax.