The amino acid sequence has to be altered in such a way as to make major innovations in highly conserved organs, brains, lungs, hearts and a long list of others.
And that can be done in Hox genes. Small changes in the amino acid sequence of the proteins of Hox genes can result in large phenotypic changes.
1a. http://www.nature.com/cgi-taf/DynaPage.taf?file=/nature/journal/vaop/ncurrent/full/nature716_fs.html
4. Zou H, Niswander L , Requirement for BMP signaling in interdigital apoptosisand scale formation. Science 1996 May 3;272(5262):738-41 "Expressionof dnBMPR in chicken embryonic hind limbs greatly reduced interdigital apoptosis and resulted in webbed feet. In addition, scales were transformed into feathers."
Not on a macroevolutionary level it doesn't.
Yes, it does. There are fossil records fine enough to watch microevolutionary changes in individuals go from species to species across genera, family, order, and even class:
Transitional individuals from one class to another
1. Principles of Paleontology by DM Raup and SM Stanley, 1971, there are transitional series between classes. (mammals and reptiles are examples of a class)
2. HK Erben, Uber den Ursprung der Ammonoidea. Biol. Rev. 41: 641-658, 1966.
Transitional individuals from one order to another
1. C Teichert "Nautiloidea-Discorsorida" and "Actinoceratoidea" in Treatise on Invertebrate Paleontology ed RC Moore, 1964
2. PR Sheldon, Parallel gradualistic evolution of Ordovician trilobites. Nature 330: 561-563, 1987. Rigourous biometric study of the pygidial ribs of 3458 specimens of 8 generic lineages in 7 stratgraphic layers covering about 3 million years. Gradual evolution where at any given time the population was intermediate between the samples before it and after it.
Transitionals across genera:
1. Williamson, PG, Paleontological documentation of speciation in cenozoic molluscs from Turkana basin. Nature 293:437-443, 1981. Excellent study of "gradual" evolution is an extremely fine fossil record.
Transitional series from one family to another in foraminerfera
1. http://www.ucmp.berkeley.edu/foram/foramintro.html
2. http://cushforams.niu.edu/Forams.htm
Speciation in the fossil record
1. McNamara KJ, Heterochrony and the evolution of echinoids. In CRC Paul and AB Smith (eds) Echinoderm Phylogeny and Evolutionary Biology, pp149-163, Clarendon Press, Oxford, 1988 pg 140 of Futuyma.
2. Kellogg DE and Hays JD Microevolutionary patterns in Late Cenozoic Radiolara. Paleobiology 1: 150-160, 1975.
When we go to transitional species then there are many more examples.
With 4 nucleotides you have 4^4 (64) possible combinations but there are only 20 amino acids. This is one common outcome of a random mutation, it's called a frameshift.
Actually, frameshift mutations are not that common. Instead, substitution mutations are much more common. Frameshifts result from insertion or deletion of nucleotides.
Basically the process is cyclical not linear. You imagine an upwardly mobile accumulation of increased complexity and favorable traits. While that happens on a micro scale in vast array macroevolutionary adaptations are far less common.
"Macroevolutionary adaptations" happen in a sequential fashion. In the macroevolution of birds, for example, the traits that we associate with birds: feathers, toothless beaks, backward pointing toes, etc, are added one at a time to the lineage. IOW, the species already has feathers before the backward pointing toes are added.
What is more most adaptive changes in the amino acid sequence that results in adaptive traits are simple repeats, no new information is being added to the genome.
Documentation, please? Document where "simple repeats" are "most adaptive changes".
Information is added by 2 mechanisms:
1. Addition of DNA. This is accomplished by the addition of repeats -- such as the ALU repeat in the human genome -- or such mutations as gene duplication, translocation, or chromosome duplication.
2. Selection. William Dembski (yes, the IDer) has demonstrated that selection adds information.
Mutations for the most part do nothing at all and the vast majority of those with an effect are deleterious.
You want specifics. Well, specific tests to determine the deleterious mutation rate has shown that deleterious mutations are only 2.6 per
1,000. That means 997.4 mutations out of 1,000 either "do nothing at all" or are beneficial.
Now, that "do nothing at all" only applies
to a particular environment. It may do something great in another environment. For instance, the mutation that yielded nylonase does nothing in most environments. But in an environment with nylon, it provides access to a new food source.
What happens as a result of the failed attempts?
The individual is screwed, but the population is unaffected. As others have reminded you, evololution happens to
populations. Since more individuals are born than the environment can support, the "failed attempts" simply die and are removed from the population.
The reptile is subject to sever deleterious effects while the natural roulette wheel spins at random.
Documentation? "Reptile" is an entire Class of thousands of species. So there is no "the" reptile.
What is more most adaptations are due to recombinations, genes being turned on and off and changes regulated at a molecular level.
Most variation is due to recombination in sexually reproducing species. Now, what happens in "recombination"? Alleles are combined in novel combinations. What this means is that some alleles are eliminated from the population because the combination doesn't work well. Other alleles are fixed in the population because the combination works very well. Once again the genetic composition of the population changes.
Now, since you admit here that those genetic combinations are "adaptations" and beneficial, now you have found a mechanism of evolution! Congratulations! You just defeated your own position.
I'm well aware of the basics, it's the innovation of increased complexity and novel genetic adaptations that are at issue in the Cambrian Explosion.
Not really. We see "novel genetic adaptations" in every adaptive radiation. The issue in the Cambrian Explosion is that this radiation happens at the beginning of evolution before many of the so-called body plans become "entrenched" and cannot change.