Log in
Register
Search
Search titles only
By:
Search titles only
By:
Forums
New posts
Forum list
Search forums
Leaderboards
Games
Our Blog
Blogs
New entries
New comments
Blog list
Search blogs
Credits
Transactions
Shop
Blessings: ✟0.00
Tickets
Open new ticket
Watched
Donate
Log in
Register
Search
Search titles only
By:
Search titles only
By:
More options
Toggle width
Share this page
Share this page
Share
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Menu
Install the app
Install
Forums
Discussion and Debate
Discussion and Debate
Physical & Life Sciences
Creation & Evolution
A simple calculation shows why evolution is impossible
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="stevevw" data-source="post: 74310156" data-attributes="member: 342064"><p>Thats the prevailing view. But from the evidence I have seen many of the neutral mutations are actually slightly deleterious. Non-beneficial mutations can be tolerated and these may be mistakenly seen as neutral. ie</p><p><em><span style="color: #00b3b3">As observed in computational systems</span><a href="https://www.nature.com/articles/nature05385#ref-CR3" target="_blank"><span style="color: rgb(0, 179, 179)">3</span></a><span style="color: #00b3b3">,</span><a href="https://www.nature.com/articles/nature05385#ref-CR4" target="_blank"><span style="color: rgb(0, 179, 179)">4</span></a><span style="color: #00b3b3">,</span><a href="https://www.nature.com/articles/nature05385#ref-CR5" target="_blank"><span style="color: rgb(0, 179, 179)">5</span></a><span style="color: #00b3b3">, negative epistasis was tightly associated with higher tolerance to mutations (robustness). Thus, under a low selection pressure, a large fraction of mutations was initially tolerated (high robustness), but as mutations accumulated, their fitness toll increased, resulting in the observed negative epistasis. </span><strong><span style="color: rgb(0, 179, 179)">These findings, supported by FoldX stability computations of the mutational effects<a href="https://www.nature.com/articles/nature05385#ref-CR6" target="_blank">6</a>, prompt a new model in which the mutational robustness (or neutrality) observed in proteins, and other biological systems, is due primarily to a stability margin, or threshold, that buffers the deleterious physico-chemical effects of mutations on fitness.</span></strong> <span style="color: #b30000"><strong>Threshold robustness is inherently epistatic—once the stability threshold is exhausted, the deleterious effects of mutations become fully pronounced, thereby making proteins far less robust than generally assumed.</strong></span></em></p><p><a href="https://www.nature.com/articles/nature05385" target="_blank">Robustness–epistasis link shapes the fitness landscape of a randomly drifting protein</a></p><p></p><p> Processes I have posted earlier associated with the EES such as developmental bias, plasticity, niche construction and extra genetic inheritance include epigenetics.</p></blockquote><p></p>
[QUOTE="stevevw, post: 74310156, member: 342064"] Thats the prevailing view. But from the evidence I have seen many of the neutral mutations are actually slightly deleterious. Non-beneficial mutations can be tolerated and these may be mistakenly seen as neutral. ie [I][COLOR=#00b3b3]As observed in computational systems[/COLOR][URL='https://www.nature.com/articles/nature05385#ref-CR3'][COLOR=rgb(0, 179, 179)]3[/COLOR][/URL][COLOR=#00b3b3],[/COLOR][URL='https://www.nature.com/articles/nature05385#ref-CR4'][COLOR=rgb(0, 179, 179)]4[/COLOR][/URL][COLOR=#00b3b3],[/COLOR][URL='https://www.nature.com/articles/nature05385#ref-CR5'][COLOR=rgb(0, 179, 179)]5[/COLOR][/URL][COLOR=#00b3b3], negative epistasis was tightly associated with higher tolerance to mutations (robustness). Thus, under a low selection pressure, a large fraction of mutations was initially tolerated (high robustness), but as mutations accumulated, their fitness toll increased, resulting in the observed negative epistasis. [/COLOR][B][COLOR=rgb(0, 179, 179)]These findings, supported by FoldX stability computations of the mutational effects[URL='https://www.nature.com/articles/nature05385#ref-CR6']6[/URL], prompt a new model in which the mutational robustness (or neutrality) observed in proteins, and other biological systems, is due primarily to a stability margin, or threshold, that buffers the deleterious physico-chemical effects of mutations on fitness.[/COLOR][/B] [COLOR=#b30000][B]Threshold robustness is inherently epistatic—once the stability threshold is exhausted, the deleterious effects of mutations become fully pronounced, thereby making proteins far less robust than generally assumed.[/B][/COLOR][/I] [URL='https://www.nature.com/articles/nature05385']Robustness–epistasis link shapes the fitness landscape of a randomly drifting protein[/URL] Processes I have posted earlier associated with the EES such as developmental bias, plasticity, niche construction and extra genetic inheritance include epigenetics. [/QUOTE]
Insert quotes…
Verification
Post reply
Forums
Discussion and Debate
Discussion and Debate
Physical & Life Sciences
Creation & Evolution
A simple calculation shows why evolution is impossible
Top
Bottom