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'Dawson's Creek' star James Van Der Beek dies at 48 after colorectal cancer battle
- Thread starter ThatRobGuy
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Pommer
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Aye, ‘umble aspirin is a “miracle” medicine and has been for well over a century, the 81mg dosage especially, since the enteric version doesn’t affect the stomach near as bad as the full “5 grain” stuff.
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Obviously there's a genetic component and certain people get an unlucky dice roll no matter what they do...
But I still think it'd be worth them looking into potential links to overuse of antibiotics and the massive uptick in SSRI usage in young people that was happening in the 90's. (both of which have an impact on the gut biome)
The stat I referenced earlier, a person born in 1990 (statistically) has double the likelihood of getting colorectal cancers compared to their parents and grandparents, that's not insignificant, and can't be explained exclusively by changing diets or bad luck.
It's not as if human genetic lines magically changed that much in the transition phase from new-wave to grunge to make that many people more susceptible to bad luck or a few extra Big Macs.
There had to be some sort of outside catalyst that was introduced driving some of it.
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There's a few different links discussing it
Why Today’s Young Adults Are 4 Times More Likely To Have Rectal Cancer
Young Americans born in 1990 now face a fourfold higher rectal cancer risk than those born in 1950. Discover the lifestyle factors and health disparities fueling this trend.
studyfinds.org
Study Finds Colorectal Cancer Rates Have Risen Dramatically in Gen X and Millennials
February 28, 2017 – A new study finds that compared to people born around 1950, when colorectal cancer risk was lowest, those born in 1990 have double the risk of colon cancer and quadruple the...
Understanding Colon Cancer Risk for the 90s Generation
Rocky Mountain Gastroenterology Associates explores the rising colon cancer risk for those born in the 90s. Stay informed & stay healthy by learning more!
www.rockymountaingastro.com
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Pommer
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What!?
The richest Nation in the history of the Earth has a health care system with nineteenth century roots, but we don’t need to rely on that paradigm no more! (Excepting we got this Great Big Military Presence that we’ve used in the past to enforce “our will” and “defend friends” and we’re so unpopular that if we lessened our defense one iota, they’d bring us down like dogs. So to keep being the richest nation in the world, we’re just going to go with that.)
The fabulously rich are happy to provide the “goods and services” that we’re going to need needing, (as soon as they tell us what they are!).
Somebody’s going to remind folks that “money” is only “money” if we all agree that it is.
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Stopped_lurking
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SSRIs has been studied (Pubmed search search term: SSRI colorectal cancer), no one has reported an increase in risk. All but one report a protective effect (the one reports no effect)
1: Coogan PF, Strom BL, Rosenberg L. Antidepressant use and colorectal cancer
risk. Pharmacoepidemiol Drug Saf. 2009 Nov;18(11):1111-4. doi: 10.1002/pds.1808.
PMID: 19623565; PMCID: PMC2783290.
2: Lee HC, Chiu WC, Wang TN, Liao YT, Chien IC, Lee Y, McIntyre RS, Chen PC,
Chen VC. Antidepressants and colorectal cancer: A population-based nested case-
control study. J Affect Disord. 2017 Jan 1;207:353-358. doi:
10.1016/j.jad.2016.09.057. Epub 2016 Oct 1. PMID: 27744223.
3: Xu W, Tamim H, Shapiro S, Stang MR, Collet JP. Use of antidepressants and
risk of colorectal cancer: a nested case-control study. Lancet Oncol. 2006
Apr;7(4):301-8. doi: 10.1016/S1470-2045(06)70622-2. PMID: 16574545.
4: Lee HK, Eom CS, Kwon YM, Ahn JS, Kim S, Park SM. Meta-analysis: selective
serotonin reuptake inhibitors and colon cancer. Eur J Gastroenterol Hepatol.
2012 Oct;24(10):1153-7. doi: 10.1097/MEG.0b013e328355e289. PMID: 22735609.
5: Zhang N, Sundquist J, Sundquist K, Ji J. Use of Selective Serotonin Reuptake
Inhibitors Is Associated with a Lower Risk of Colorectal Cancer among People
with Family History. Cancers (Basel). 2022 Nov 29;14(23):5905. doi:
10.3390/cancers14235905. PMID: 36497383; PMCID: PMC9741129.
6: Beton-Mysur K, Brożek-Płuska B. Exploring the Impact of Citalopram on Human
Colon Cells: Insights into Antidepressant Action Beyond the Brain. Spectrochim
Acta A Mol Biomol Spectrosc. 2025 Dec 15;343:126464. doi:
10.1016/j.saa.2025.126464. Epub 2025 May 22. PMID: 40466489.
7: Zhang N, Sundquist J, Sundquist K, Zhang ZG, Ji J. Combined Use of Aspirin
and Selective Serotonin Reuptake Inhibitors Is Associated With Lower Risk of
Colorectal Cancer: A Nested Case-Control Study. Am J Gastroenterol. 2021 Jun
1;116(6):1313-1321. doi: 10.14309/ajg.0000000000001192. Erratum in: Am J
Gastroenterol. 2021 Nov 1;116(11):2310. doi: 10.14309/ajg.0
000000000001520.
PMID: 33661146
There were some results that focused more on potential mechanism instead of epidemiology. Please check that I didn't miss anything relevant.
This is of course provisional, future findings can change the picture. As it stands now it seems that SSRIs don't increase the risk of colorectal cancer.
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I think that's where there's a research gap that needs to be investigated... That's why I mentioned in my initial post about that, that it's a potential causal link that's worth researching now that the kids who started getting prescribed that in the 90's are just now reaching the age where the early onset colorectal cancers would start showing up.
Most, if not all, of the studies that have been done thus far involve studying people who started on them as adults, and tracked their cancer outcomes.
From Stanford:
A few of the most common SSRIs are approved by the FDA for use in kids and teens, and others that are approved for use in adults are commonly prescribed off-label for adolescents.
Side effects of these medications in adolescents include weight gain, gastrointestinal issues, decreased libido and insomnia.
It wouldn't be the first class of drugs that has a very different impact on fully grown adults than it does to adolescents who are still developing.
Even something as common as aspirin, relatively benign in adults with minimal risks, but then they found there's a very different risk profile for teenagers.
Reye syndrome - Wikipedia
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When you consider the world as a whole, diet doesn't seem to be the smoking gun (or at least not the only one)
Colorectal cancer statistics | World Cancer Research Fund
Latest statistics on colorectal cancer rates around the world. Colorectal cancer or bowel cancer is the 3rd most common cancer globally
www.wcrf.org
Colon Cancer Rate by Country 2026
Discover population, economy, health, and more with the most comprehensive global statistics at your fingertips.
The diets (and obesity levels) in Japan are far more favorable compared to the US by conventional nutrition wisdom. Yet they apparently have one of the highest per 100k rates in the world.
The Japanese Diet: Benefits, Food List, and Meal Plan
A traditional Japanese diet is typically rich in nutrients and believed to provide an array of health benefits. This article covers everything you need to know about a traditional Japanese Diet.
www.healthline.com
What even more interesting is when you look at that last column (from the WorldPopulationReview link) where it shows how it's currently trending. Our rates are on the decline, whereas, countries that you'd expect to be doing much better are on steep inclines.
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rambot
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Yes but Japan also has the highest aged population so you are BOUND to find greater numbers of colo-rectal patients. I WOULD be curious about an age cohort comparison.When you consider the world as a whole, diet doesn't seem to be the smoking gun (or at least not the only one)
Colorectal cancer statistics | World Cancer Research Fund
Latest statistics on colorectal cancer rates around the world. Colorectal cancer or bowel cancer is the 3rd most common cancer globally
Colon Cancer Rate by Country 2026
Discover population, economy, health, and more with the most comprehensive global statistics at your fingertips.worldpopulationreview.com
The diets (and obesity levels) in Japan are far more favorable compared to the US by conventional nutrition wisdom. Yet they apparently have one of the highest per 100k rates in the world.
World Health Organization listed China, Us, and Japan with highest CR rates (it's mostly european countries and canada). What a strange assortment!
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The diets are all over the place when you look at it.
For the longest time we were told red meat was a major factor.
Yet the countries that consume a lot of it are on the decline somehow.
US, New Zealand, Australia, and Canada all have declining colorectal cancer rates that are moving in the right direction (despite obesity itself and other cardiovascular issues increasing)
But places like Taiwan, Thailand, and Denmark (all of which only consume about 1/3 of the red meat we do) have rates that seem to be increasing quite a bit.
Perhaps toxins in the aquatic life playing a factor?
When I sort by that last column (that shows the % change from 1990 to 2017), the nations where it seems to be increasing seem to be a lot of the ones that have various forms of fish as a staple.
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