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Ozempic and Gila Monsters

Bob Crowley

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Ozempic is being produced for Diabetes 2 and to help control obesity. But apparently it owes its origin to the Gila Monster, or at least some of it.


Enter a poisonous lizard

In the 1980s John Pisano, a biochemist with a penchant for venoms, and a young gastroenterologist Jean-Pierre Raufman were working with poisonous lizard venom from the Gila monster, a slow-moving reptile native to the south of the United States and north of Mexico. By the 1990s, Pisano, Raufman and colleague John Eng identified a hormone-like molecule they called exendin-4. This stimulated insulin secretion via action at the same receptor as GLP-1.

Excitingly, exendin-4 was not quickly metabolised by the body, and so might be useful as a diabetic therapeutic.
 
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