Is Jesus the only son of God?

John 3:

16 For God so loved the world that he gave his one and only Son, that whoever believes in him shall not perish but have eternal life.

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one and only
μονογενῆ (monogenē)
Adjective - Accusative Masculine Singular
Strong's 3439: Only, only-begotten; unique. From monos and ginomai; only-born, i.e. Sole.

Jesus is the unique Son of God. However, the term son of God has other meanings.

Angels were sons of God, Job 1:

6 Now there was a day when the sons of God came to present themselves before the LORD, and Satan also came among them.

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Ellicott's Commentary for English Readers:

The phrase probably means the angels

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Pulpit is similar:

By "the sons of God" it is generally admitted that, in this place, the angels are meant (so again in Job 38:7). The meaning of the phrase is probably different in Genesis 6:2.

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The same phrase appears in Genesis 6:

2 the sons of God saw that the daughters of humans were beautiful, and they married any of them they chose.

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Ellicott explained:

Of the sons of the Elohim there are three principal interpretations: the first, that of the Targums and the chief Jewish expositors, that they were the nobles, and men of high rank;
the second, that they were angels ...
The third, and most generally accepted interpretation in modern times, is that the sons of the Elohim were the Sethites, and that when they married for mere lust of beauty, universal corruption soon ensued.

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In the OT, Christians are sons (children) of God, Matthew 5:

9 Blessed are the peacemakers, for they shall be called sons of God.

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Is Jesus the only son of God?

Jesus is the unique Son of God. Angels, giants, kings, and judges are sometimes called sons of God. Christians are children of God.