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Ulrich Zwingli is often accused of making up the doctrine that the Lord's Supper is a symbolic memorial of Christ's suffering, rather than literally the body and blood of Christ. But there doesn't seem to be universal agreement in the early Christian writings for transubstantiation:
The Didache, written in the late-first or early-second century, referred to the elements of the Lord’s table as “spiritual food and drink” (The Didache, 9). The long passage detailing the Lord's Table in this early Christian document gives no hint of transubstantiation whatsoever.
Justin Martyr (110–165) spoke of “the bread which our Christ gave us to offer in remembrance of the Body which He assumed for the sake of those who believe in Him, for whom He also suffered, and also to the cup which He taught us to offer in the Eucharist, in commemoration of His blood"(Dialogue with Trypho, 70).
Clement of Alexandria explained that, “The Scripture, accordingly, has named wine the symbol of the sacred blood” (The Instructor, 2.2).
Origen similarly noted, “We have a symbol of gratitude to God in the bread which we call the Eucharist” (Against Celsus, 8.57).
Cyprian (200–258), who sometimes described the eucharist using very literal language, spoke against any who might use mere water for their celebration of the Lord’s Table. In condemning such practices, he explained that the cup of the Lord is a representation of the blood of Christ: “I marvel much whence this practice has arisen, that in some places, contrary to Evangelical and Apostolic discipline, water is offered in the Cup of the Lord, which alone cannot represent the Blood of Christ” (Epistle 63.7).
Eusebius of Caesarea (263–340) espoused a symbolic view in his Proof of the Gospel:
For with the wine which was indeed the symbol of His blood, He cleanses them that are baptized into His death, and believe on His blood, of their old sins, washing them away and purifying their old garments and vesture, so that they, ransomed by the precious blood of the divine spiritual grapes, and with the wine from this vine, "put off the old man with his deeds, and put on the new man which is renewed into knowledge in the image of Him that created him." . . . He gave to His disciples, when He said, "Take, drink; this is my blood that is shed for you for the remission of sins: this do in remembrance of me." And, "His teeth are white as milk," show the brightness and purity of the sacramental food. For again, He gave Himself the symbols of His divine dispensation to His disciples, when He bade them make the likeness of His own Body. For since He no more was to take pleasure in bloody sacrifices, or those ordained by Moses in the slaughter of animals of various kinds, and was to give them bread to use as the symbol of His Body, He taught the purity and brightness of such food by saying, “And his teeth are white as milk” (Demonstratia Evangelica, 8.1.76–80).
Athanasius (296–373) similarly contended that the elements of the Eucharist are to be understood spiritually, not physically: “[W]hat He says is not fleshly but spiritual. For how many would the body suffice for eating, that it should become the food for the whole world? But for this reason He made mention of the ascension of the Son of Man into heaven, in order that He might draw them away from the bodily notion, and that from henceforth they might learn that the aforesaid flesh was heavenly eating from above and spiritual food given by Him.” (Festal Letter, 4.19)
Augustine (354–430), also, clarified that the Lord’s Table was to be understood in spiritual terms: “Understand spiritually what I said; you are not to eat this body which you see; nor to drink that blood which they who will crucify me shall pour forth. . . . Although it is needful that this be visibly celebrated, yet it must be spiritually understood” (Exposition of the Psalms, 99.8).
He also explained the eucharistic elements as symbols. Speaking of Christ, Augustine noted: “He committed and delivered to His disciples the figure [or symbol] of His Body and Blood.” (Exposition of the Psalms, 3.1).
And in another place, quoting the Lord Jesus, Augustine further explained: “‘Except ye eat the flesh of the Son of man,’ says Christ, ‘and drink His blood, ye have no life in you.’ This seems to enjoin a crime or a vice; it is therefore a figure [or symbol], enjoining that we should have a share in the sufferings of our Lord, and that we should retain a sweet and profitable memory of the fact that His flesh was wounded and crucified for us (On Christian Doctrine, 3.16.24).
Did the Early Church Teach Transubstantiation?