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Where did the laws of nature come from?

Loudmouth

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An error is an error is an error. A mutation is an error in our DNA which is already coded to function properly.

If we took the chimp genome and changed 35 million bases and added or deleted multiple bases at 5 million other places in the genome, would you get a functional species?

The answer is that you would. We call them humans.

How can you claim that you will not get function after a mutation when humans depend on those mutations for our function?


The codes are the right ones and are like a language which need to spell out a particular language to work properly that will produce life. A mutation causes that specific language not to read properly. Its got nothing to do with improvements and all to do with keeping the right language in the first place.

That is completely false. A gene with a mutation reads just fine. Humans and chimps are separated by 40 million mutations, yet both of our genomes read just fine.
 
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Loudmouth

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Because the benefit often cited from random mutations is short lived. They either come with a cost because the benefit was produced by altering the existing genetic sequences and that alteration also causes some slight fitness cost ie the benefit is the result of switching off a function which may have had use for something else which will cause some affect to the creature.

What are the costs from the 40 million mutations that separate us from chimps? Just answer this one question.
 
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stevevw

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If we took the chimp genome and changed 35 million bases and added or deleted multiple bases at 5 million other places in the genome, would you get a functional species?
The problem is changing one of those small bases doesn't do anything on its own and there needs to be many added together to make a change big enough to be selected. But thats not how it works. Mutations added together dont build toward something that has function because its a blind process and its more likely to add up to something negative which gets selected out or makes life less fit rather than fitter.

The answer is that you would. We call them humans.
And the amount of mutations needed to do that we call cancer.

How can you claim that you will not get function after a mutation when humans depend on those mutations for our function?
A mutation is an error in the copying of what is already good and working. Its a fallacy that mutations lead to better and fitter life. There are many other ways life can gain genetic material besides mutations and natural selection. Just look at the facts of what mutations do, I have posted two dozen papers showing that mutations lead to fitness costs good, bad or neutral.

That is completely false. A gene with a mutation reads just fine. Humans and chimps are separated by 40 million mutations, yet both of our genomes read just fine.
Thats because you assume that one morphed from the other in the first place so of course your going to think that it all works that way. Your logic is to assume it happened so it must be true despite the dozen papers that show mutations dont deliver better and fitter life and have limits to creating more complexity.

If a gene with a mutation is OK then why does our DNA send out machines to try to rectify that error that the mutation has made and put things back to their original state. What may look OK is just because the DNA has tolerated that error for the time being. But its still en error that isn't great enough to have an effect on its own,. But given more mutations it is inevitable that they will add up to a bigger cost to fitness and not a better and fitter life. Errors, mistakes or damage to what is already OK dont make things better.
 
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stevevw

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What are the costs from the 40 million mutations that separate us from chimps? Just answer this one question.
There are no costs because it didn't happen. You are assuming it happened so therefore assuming it works and doesn't have a cost. But when we look at the actual steps to make it happen thats when we see that it cant because of the costs that happen even with just small changes to proteins. Proteins are specific and require very finite structures to be exactly right. They cannot tolerate mutations that change those structures.
 
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There are no costs because it didn't happen...
Are you seriously saying that humans and chimps do not have a common ancestor so that "40 million mutations" do not separate us from chimps, stevevw :eek:?

30 June 2016 stevevw: Do humans and chimps have a common ancestor?

You seem to have missed addressing:
  1. 28 June 2016 stevevw: Douglas Axe discredited his competence by associating with the Discovery Institute by being the director of the DI-funded Biologic Institute.
  2. 28 June 2016 stevevw: The evidence is that Douglas Axe is not an expert on evolution - he has published 9 paper in 29 years which makes him an expert on nothing (experts publish multiple papers per year!).
  3. 28 June 2016 stevevw: At least one of those papers was slightly dubious and wrongly cited by IDiots as evidence against evolution: Axe (2004) and the evolution of enzyme function
Still not addressed or acknowledged:
  1. 15 June 2016 stevevw: It is a lie to state that dogs and GMO show limits to evolution. They are not examples of evolution. There seems no limit to what we can breed/engineer.
  2. 21 June 2016 stevevw: The fantasy that we must be able to create new mammal species, e.g. dogs into cats, is not a limit to evolution!
  3. 21 June 2016 stevevw: Now you do not need to ignorantly repeat the "most mutations are harmful" myth.
  4. 23 June 2016 stevevw: Papers that do not state there is a limit to evolution are not evidence of limits to evolution.
  5. 23 June 2016 stevevw: Please read and acknowledge the scientific evidence that makes the idea that microevolution does not lead to macroevolution very ignorant.
  6. 23 June 2016 stevevw: The different definitions of species are not evidence of limits to evolution.
  7. 23 June 2016 stevevw: Ignorance about Darwin's original work and evolution should be remedied by learning about evolution. I suggest you start with Wikipedia.
  8. 23 June 2016 stevevw: None of the paper you cited state that most mutations are harmful.
 
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stevevw

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Are you seriously saying that humans and chimps do not have a common ancestor so that "40 million mutations" do not separate us from chimps, stevevw :eek:?


30 June 2016 stevevw: Do humans and chimps have a common ancestor?
This is another example of giving mutations more creative power than they have. You think that just producing 40 million mutations and hey presto we have a human is possible. Each and every mutational change has to be a benefit on its own as well as in conjunction with other mutations and be in exactly the right place to spell out the precise written code or create that specific structure in the proteins to change from one type of creature to the next. So its not just a case of producing 40 million mutations as some try to make out but 40 million mutations in the right place as well as being a continual benefit when added to other mutations.

Because the construction space for all possible sequence combinations is so great that 40 million that have to be just right would then need to be billions of other mutations that are not right to end up finding the 40 million correct ones. That means there will be many many negative ones as well mixed in which will cause any benefit to be withered as tests have shown. That means it will take much more time to go through the hit and miss process of working through all these mutations. The chances of each and every mutation finding the exact language code would be like trying to get a jackpot combination of around 200 plus columns right each time for 40 million times. The odds for that are impossible. Tests show that even for small functional changes will hit fitness walls and take more time than there is available for the evolution of an ape to a human. So its easy to tell stories but harder to produce the evidence.

  1. Already addressed if you check
Also already addressed, I think its you who is ignoring and not acknowledging things.
Jun 21, 2016 #1211
Jun 20, 2016 #1202
Jun 17, 2016 #1199
 
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stevevw

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A fossil record does prove a theory scientifically as you put it. Thinking that we actually can duplicate millions of years of evolution of the eye is a fantasy. Especially since it has already been done and recorded in that fossil record. Add in that we apply the mechanisms to natural selection to photosensitive cells in computer simulations and get focused lens eyes: A pessimistic estimate of the time required for an eye to evolve (Nilsson DE, Pelger S. 1994)

You may want to read up on the evolution of the eye, e.g. Evolution of the eye

New information is created in the genes all the time- this is called mutation :eek:!
A bacteria that could not eat something has gained the new information to eat that, e.g. nylon that has never existed in nature: Nylon-eating bacteria.
See the E. coli Long-term Experimental Evolution Project (bacteria gain new information - a wide array of genetic changes).
Look up how bacteria flagella may have evolved from the Type III secretory and transport system.
Look up how the vertebrate blood clotting cascade evolved: Step-by-step evolution of vertebrate blood coagulation.
Read any biology text book for many other examples of species gaining new information. Speciation which we have observed happening is genes gaining enough new information that a population is distant from another population!

I have not mentioned any such mechanisms.
Citations, please stevew, to the scientific literature on these mechanisms that you talk about which that that they "diminish it [natural selection] to the side lines or say that it may not play much of a role at all".
In going back over the posts to check if I had already answered the questions you claim I didn't I found a post I actually missed. It is amusing to see how those who support the magic of darwins theory believe that it is capable of evolving eyes 50 to 100 times over and over again just like it was a design with a preformed form work ready to be used again. Its funny how it acts like design yet its not designed. For a blind process it sure finds the right stuff over and over again. When ready wikipedia which was used as your support rather than a peer reviewed paper its amazing the type of language that is used to describe how eyes evolved. Language such as "Complex eyes appear to have first evolved within a few million years". I'm glad they say appeared because thats about as close as it gets. Like Dawkins states evolution appears to look like design but of course he reckons its not.

Evolution is good at describing how something may happen but cannot back that up with detailed support showing the step by step process of how each and every small component evolved from what wasn't there in the first place. They start with the eye spot but never describe how this came about which is quite complex in itself when you consider its not just a patch of skin but also has to simultaneously have neurons and connections to the right areas of the brain to be able to register that its sensing light. Otherwise it may as well be a window that doesn't think or even know its a light receptor. Then they mention certain stages which all have giant gaps just like the fossil record which are suppose to complete the story. In between there are thousands of steps that require many mutations often at the same time to build the eye in detail.
 
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stevevw

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Citation needed.
Diminishing Returns Epistasis Among Beneficial Mutations Decelerates Adaptation
These results provide the first evidence that patterns of epistasis may differ for within- and between-gene interactions during adaptation and that diminishing returns epistasis contributes to the consistent observation of decelerating fitness gains during adaptation.
http://www.sciencemag.org/content/332/6034/1190.abstract
Estimation of spontaneous genome-wide mutation rate parameters: whither beneficial mutations? (Thomas Bataillon)
Abstract……It is argued that, although most if not all mutations detected in mutation accumulation experiments are deleterious, the question of the rate of favourable mutations (and their effects) is still a matter for debate.
http://www.nature.com/hdy/jour.....7270a.html

And the answer is yes, at least according to the people who study this kind of stuff for a living.
Similarly, genetic drift increases the likelihood that a potentially beneficial mutation will be lost before it becomes widespread in the population. The net effect of genetic drift in such populations is "to encourage the fixation of mildly deleterious mutations and discourage the promotion of beneficial mutations,",
The frailty of adaptive hypotheses for the origins of organismal complexity
http://www.pnas.org/content/104/suppl_1/8597.full

Then exactly how does it work and how does that provide support for your version of creationism?
I am not posting or saying anything about any creationism. I am merely pointing out that Darwin's theory of evolution is not supported as much as you think and I am posting support why. I am posting support for other reasons that contribute to how life changes based on scientific evidence.

As explained above, unless the benefit is great it won’t be selected. To create the vast complexity and variety we see today you will need many great beneficial mutations to be selected. The non adaptive forces work against selection so natural selection plays a minor role in how life can change. It is more likely to happen from non selective and adaptive methods such as those I have posted before like HGT, symbiosis, epigentics, cross breeding and how physical development influences the generation of variation (developmental bias); how the environment directly shapes organisms’ traits (plasticity); how organisms modify environments (niche construction); and how organisms transmit more than genes across generations (extra-genetic inheritance). Evolution places to much importance of natural selection and random mutations being the only way that life can develop and change which is almost making it a god in itself by giving it so much creative power.
http://www.nature.com/news/does-evolutionary-theory-need-a-rethink-1.16080
Darwinian evolution in the light of genomics
Evolutionary-genomic studies show that natural selection is only one of the forces that shape genome evolution and is not quantitatively dominant, whereas non-adaptive processes are much more prominent than previously suspected. There is no consistent tendency of evolution towards increased genomic complexity, and when complexity increases, this appears to be a non-adaptive consequence of evolution under weak purifying selection rather than an adaptation.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651812/

Evidence for what? Just look at any c
ollege level evolution textbook and you'll find thousands of pages of evidence for the actual scientific approach to this subject.
Yes look at the college evolution books. They all speak of the story of evolution. They talk about micro evolution which everyone agrees happens. But there is little or no support for detailed explanations and evidence for how macro evolution happens. How evolution can evolve complex parts. How tests can show that they can get around this entropy problem. How the net effect is diminishing fitness. The papers I am posting are what the books are based on.
Nothing in Evolution Makes Sense Except in Light of Population Genetics
“Since the Modern Synthesis, most expositions of the evolutionary process have focused on microevolutionary mechanisms. Millions of biology students have been taught the view (from population genetics) that ‘evolution is change in gene frequencies.’ Isn't that an inspiring theme? This view forces the explanation toward mathematics and abstract descriptions of genes, and away from butterflies and zebras….
http://www.pnas.org/content/104/suppl_1/8597.full

Uh, you posted the same link twice.
That’s because I am having to restate the same thing over again because you don’t read it and ignore it.

Anyway, that's nice. The paper does nothing to support your faith that beneficial mutations don't happen though, so I'm not sure why your brought it up.
I mentioned in my last post that beneficial mutations are short lived. So how do you now claim that I said there are no beneficial mutations. I am saying what may be a benefit in one situation temporarily turns out to be a negative and quite the opposite ie genetic entropy. The paper that you are referring to states that what is a beneficial mutations at one point are not in the end when it counts in creating new genetic info for building new types of features and creatures. Organisms can tolerate small negative mutations which may seem like a neutral or even beneficial effect. But when other mutations are added a threshold is reached where the total accumulated effect of the mutations have a fitness cost to the organism rather then a fitness gain. Even when the effect may seem beneficial such as with antibiotic resistance there is still a fitness cost that comes with this because the organism has to tolerate a loss of info and change to what is already good to gain that benefit shown in this paper below.

Only the built-in safety mechanisms in the cell hold off mutational catastrophe.

Robustness–epistasis link shapes the fitness landscape of a randomly drifting protein


These findings, supported by FoldX stability computations of the mutational effects6, prompt a new model in which the mutational robustness (or neutrality) observed in proteins, and other biological systems, is due primarily to a stability margin, or threshold, that buffers the deleterious physico-chemical effects of mutations on fitness. Threshold robustness is inherently epistatic—once the stability threshold is exhausted, the deleterious effects of mutations become fully pronounced, thereby making proteins far less robust than generally assumed.
http://www.nature.com/nature/journal/v444/n7121/full/nature05385.html

 
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KCfromNC

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Diminishing Returns Epistasis Among Beneficial Mutations Decelerates Adaptation
These results provide the first evidence that patterns of epistasis may differ for within- and between-gene interactions during adaptation and that diminishing returns epistasis contributes to the consistent observation of decelerating fitness gains during adaptation.

So? How is this relevant to your claim that benefits from beneficial mutations are short lived? This is saying that in some cases the effects of multiple beneficial mutations isn't a strictly additive benefit to fitness.

Estimation of spontaneous genome-wide mutation rate parameters: whither beneficial mutations? (Thomas Bataillon)
Abstract……It is argued that, although most if not all mutations detected in mutation accumulation experiments are deleterious, the question of the rate of favourable mutations (and their effects) is still a matter for debate.

Unless the rate is zero, what's the problem?

Similarly, genetic drift increases the likelihood that a potentially beneficial mutation will be lost before it becomes widespread in the population. The net effect of genetic drift in such populations is "to encourage the fixation of mildly deleterious mutations and discourage the promotion of beneficial mutations,",
The frailty of adaptive hypotheses for the origins of organismal complexity
http://www.pnas.org/content/104/suppl_1/8597.full

Unless it eliminates beneficial mutations completely, this is another example of the science contradicting your belief.

I am not posting or saying anything about any creationism.

Sure you are. You think an intelligent designer created a set of original species with all of the genetic material they'd ever need. I know that creationism gets a bad rap and you wouldn't want to be associated with that, but the way to do that is to stop proposing creationist ideas.

As explained above, unless the benefit is great it won’t be selected.

Explained where, exactly?

The non adaptive forces work against selection so natural selection plays a minor role in how life can change. It is more likely to happen from non selective and adaptive methods such as those I have posted before

Citation needed.

http://www.nature.com/news/does-evolutionary-theory-need-a-rethink-1.16080
Darwinian evolution in the light of genomics
Evolutionary-genomic studies show that natural selection is only one of the forces that shape genome evolution and is not quantitatively dominant, whereas non-adaptive processes are much more prominent than previously suspected. There is no consistent tendency of evolution towards increased genomic complexity, and when complexity increases, this appears to be a non-adaptive consequence of evolution under weak purifying selection rather than an adaptation.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651812/

Why are you posting a paper about increases in complexity? That's a different topic entirely.

Yes look at the college evolution books. They all speak of the story of evolution. They talk about micro evolution which everyone agrees happens. But there is little or no support for detailed explanations and evidence for how macro evolution happens.

Come on, you don't even need to get into college courses for this. See e.g. the first set of bullets at http://apcentral.collegeboard.com/apc/public/repository/ap11_biology_form_b_q4.pdf

I mentioned in my last post that beneficial mutations are short lived.

Now all you have to do is support that claim.

I am saying what may be a benefit in one situation temporarily turns out to be a negative and quite the opposite

As does mainstream biology. Perhaps you should investigate why the people who study this for a living don't seem to think that it supports your version of creationism.
 
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This is another example of giving mutations more creative power than they have.
That is an example of totally not understanding a simple yes/no question.
30 June 2016 stevevw: Do humans and chimps have a common ancestor?

Checked and no replies to my 28 June 2016 points about Douglas Axe so they have not been addressed.
  1. 28 June 2016 stevevw: Douglas Axe discredited his competence by associating with the Discovery Institute by being the director of the DI-funded Biologic Institute.
  2. 28 June 2016 stevevw: The evidence is that Douglas Axe is not an expert on evolution - he has published 9 paper in 29 years which makes him an expert on nothing (experts publish multiple papers per year!).
  3. 28 June 2016 stevevw: At least one of those papers was slightly dubious and wrongly cited by IDiots as evidence against evolution: Axe (2004) and the evolution of enzyme function
Also already addressed, I think its you who is ignoring and not acknowledging things.
Jun 21, 2016 #1211
Jun 20, 2016 #1202
Jun 17, 2016 #1199
Posts with the ignorance that evolution is breeding, irrelevant links, etc. do not address what I have pointed out:
  1. 15 June 2016 stevevw: It is a lie to state that dogs and GMO show limits to evolution. They are not examples of evolution. There seems no limit to what we can breed/engineer.
  2. 21 June 2016 stevevw: The fantasy that we must be able to create new mammal species, e.g. dogs into cats, is not a limit to evolution!
  3. 21 June 2016 stevevw: Now you do not need to ignorantly repeat the "most mutations are harmful" myth.
  4. 23 June 2016 stevevw: Papers that do not state there is a limit to evolution are not evidence of limits to evolution.
  5. 23 June 2016 stevevw: Please read and acknowledge the scientific evidence that makes the idea that microevolution does not lead to macroevolution very ignorant.
  6. 23 June 2016 stevevw: The different definitions of species are not evidence of limits to evolution.
  7. 23 June 2016 stevevw: Ignorance about Darwin's original work and evolution should be remedied by learning about evolution. I suggest you start with Wikipedia.
  8. 23 June 2016 stevevw: None of the paper you cited state that most mutations are harmful.
Addressing them could be statements like:
  1. I, stevevw, acknowledge that dog breeding and genetic engineering are not examples of evolution.
  2. I, stevevw, acknowledge that it is impossible for us (currently!) to change dogs into cats.
  3. I, stevevw, now know the scientific evidence that most mutations are neutral.
  4. I, stevevw, quote where in the papers the author state that they show limits to evolution.
  5. I, stevevw, have learned the scientific evidence that microevolution leads to macroevolution and so will no longer assert that this cannot happen. Or I have scientific evidence that microevolution cannot lead to macroevolution.
  6. I, stevevw, know that different definitions of species are not evidence of limits to evolution.
  7. I, stevevw, know that the modern theory of evolution is not "Darwinism".
  8. I, stevevw, will quote the authors of these papers stating that most mutations are harmful.
 
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stevevw

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So? How is this relevant to your claim that benefits from beneficial mutations are short lived? This is saying that in some cases the effects of multiple beneficial mutations isn't a strictly additive benefit to fitness
No its saying in most cases when beneficial mutations are added together they incur a fitness cost. So this is supporting what I said in that what can seem like a benefit on its own becomes a negative when mixed with other mutations and multiple mutations are needed to make anything significant in evolution. So mutations together dont build better and fitter life but the opposite. Humans carry many negative mutations that are deteriorating our genomes.

Unless the rate is zero, what's the problem?
The first problem is whether there is the type of beneficial mutations that lead to increased function, complexity and fitness in the first place. What is cited as a benefit may just be a organism tolerating slightly negative mutations or the change that has brought the perceived benefit is actually negative anyway because it is changing what was already good which will have a cost even if it is that the organism has to use more energy to deal with that change.

For there to be new features and creatures beneficial mutations need to be more than very rare and need to be significant to be selected. Something around zero is not going to be often or great enough and have enough influence especially if its claimed to have created the vast and immense amount of complexity and variety we see in life. But not just that evidence says that no matter if mutations are beneficial, neutral or negative they are a cost to fitness and cannot go beyond certain limits because they are errors that are changing what is already good and working.

Similarly, genetic drift increases the likelihood that a potentially beneficial mutation will be lost before it becomes widespread in the population. The net effect of genetic drift in such populations is "to encourage the fixation of mildly deleterious mutations and discourage the promotion of beneficial mutations,",
The frailty of adaptive hypotheses for the origins of organismal complexity
http://www.pnas.org/content/104/suppl_1/8597.full

Unless it eliminates beneficial mutations completely, this is another example of the science contradicting your belief.
You are assuming that because some of the science may say that there is some benefit even if it’s slim pickings it is then saying that this is enough to create all of life. There is a big difference in some possible slightly rare beneficial mutation and there being enough to be a significant benefit that would create the complex variety we see in life.

Slight benefits don’t add up to much and on their own they get lost in the many other mutations that are not benefits. It would take more time then evolution claims to have them build up to all the life we see even if they did hang around and build up slowly according to the evidence, Supporters of darwins theory want to find beneficial mutations and want to elevate them and give them more credit than they have. they have to as this is the only source of all the complex variety we see. But how can a source that is basically damage to the codes that make life produce something better.

In addition, one can just as easily point to a long list of pathologies that can arise from an overly rapid proliferation of a new phenotype, and such scenarios have motivated a completely alternative, and equally speculative, view, that s(election can favor mechanisms that suppress evolvability 103). Furthermore, theoretical studies have shown that the kinds of complexities that are often focused on by those enamored with evolvability (e.g., increased dimensionality and modularity) can actually inhibit the rate of adaptive evolution.

"What is in question is whether natural selection is a necessary or sufficient force to explain the emergence of the genomic and cellular features central to the building of complex organisms."
http://www.pnas.org/content/104/suppl_1/8597.full


The effects of low-impact mutations in digital organisms
"it is important for biologists to realistically appraise what selection can and cannot do under various circumstances. Selection may neither be necessary nor sufficient to explain numerous genomic or cellular features of complex organisms."
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102618/

Sure you are. You think an intelligent designer created a set of original species with all of the genetic material they'd ever need. I know that creationism gets a bad rap and you wouldn't want to be associated with that, but the way to do that is to stop proposing creationist ideas.
The difference is I support the idea that life can evolve to a point through tapping into that genetic material and create variations of each type of creature. But if you consider this concept is basically the same for theistic evolution. The only difference is the point at which God has intervened. Whether He places that genetic info and programming into a single celled organism or more complex ones doesn't matter. The instructions for life whether through processes of evolution or non adaptive mechanisms needs the intervention of intelligent agent such as God to make it happen.

Life and the creation of more complex organism doesn't create itself through purely naturalistic processes and come from nothing for which Darwin's theory promotes. Scientific tests show that evolution cannot explain how complex variety can come into existence and continue to be created through a self creating naturalistic process. That is why supporters of evolution are appealing to more and more design capabilities and powers from evolution because much of what we see is beyond the explanations for what Darwin's theory is capable of.

Creationism doesn't use any of this and appeals to purely supernatural creation for all life and believes what we see was all created. They also believe that life and all existence is only a few thousand years old. In some ways supporters of Darwin's Evolution are appealing more to unrealistic powers of creation by speculating that a blind process based on assumption which hasn't been scientifically verified can create everything we see and dogmatically stick to it no matter what.

Explained where, exactly?
You are obviously either not reading the papers or ignoring certain parts that are showing the evidence. Look at the above papers for starters which show that beneficial mutations are overcome by other mutations and the effect is not great enough to be selected or gain a foothold to keep adding towards creating complex features. IE,
The net effect of genetic drift in such populations is "to encourage the fixation of mildly deleterious mutations and discourage the promotion of beneficial mutations,",. increased dimensionality and modularity) can actually inhibit the rate of adaptive evolution.

But here are other papers I have posted that say the same
Here, it is argued that random genetic drift can impose a strong barrier to the advancement of molecular refinements by adaptive processes.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503168/

Similarly, genetic drift increases the likelihood that a potentially beneficial mutation will be lost before it becomes widespread in the population.
http://www.ncbi.nlm.nih.gov/pubmed/17494740

Citation needed.
Are you serious, I must have posted this evidence 10 times. How can you say that you want me to cite it again? You’re obviously not following the link because you don’t want to make the connection as this will show that I am correct. Here it is again.

The frailty of adaptive hypotheses for the origins of organismal complexity.

Numerous aspects of genomic architecture, gene structure, and developmental pathways are difficult to explain without invoking the nonadaptive forces of genetic drift and mutation.
These issues are examined in the context of the view that the origins of many aspects of biological diversity, from gene-structural embellishments to novelties at the phenotypic level, have roots in nonadaptive processes,

http://www.ncbi.nlm.nih.gov/pubmed/17494740

The evolution of genetic networks by non-adaptive processes
Although numerous investigators assume that the global features of genetic networks are moulded by natural selection, there has been no formal demonstration of the adaptive origin of any genetic network. This Analysis shows that many of the qualitative features of known transcriptional networks can arise readily through the non-adaptive processes of genetic drift, mutation and recombination, raising questions about whether natural selection is necessary or even sufficient for the origin of many aspects of gene-network topologies.
http://www.nature.com/nrg/journal/v8/n10/full/nrg2192.html

Why are you posting a paper about increases in complexity? That's a different topic entirely.
How the papers talking about the inability of beneficial mutations to increase complexity.

Now all you have to do is support that claim.
Ah if you go back and check my posts you will find I have already posted support for this. There is support for this in this post as well in the above papers.

As does mainstream biology. Perhaps you should investigate why the people who study this for a living don't seem to think that it supports your version of creationism.
Its not about creationism as stated before. All that I am posting is purely to do with the science as supported by the papers posted. Its about whether evolution through chance random mutations and natural selection can produce the complexity and variety we see in life or whether it is through other sources such as non adaptive ones that use pre existing genetic info.
 
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Heissonear

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Are you seriously saying that humans and chimps do not have a common ancestor so that "40 million mutations" do not separate us from chimps, stevevw :eek:?

30 June 2016 stevevw: Do humans and chimps have a common ancestor?

You seem to have missed addressing:
  1. 28 June 2016 stevevw: Douglas Axe discredited his competence by associating with the Discovery Institute by being the director of the DI-funded Biologic Institute.
  2. 28 June 2016 stevevw: The evidence is that Douglas Axe is not an expert on evolution - he has published 9 paper in 29 years which makes him an expert on nothing (experts publish multiple papers per year!).
  3. 28 June 2016 stevevw: At least one of those papers was slightly dubious and wrongly cited by IDiots as evidence against evolution: Axe (2004) and the evolution of enzyme function
Still not addressed or acknowledged:
  1. 15 June 2016 stevevw: It is a lie to state that dogs and GMO show limits to evolution. They are not examples of evolution. There seems no limit to what we can breed/engineer.
  2. 21 June 2016 stevevw: The fantasy that we must be able to create new mammal species, e.g. dogs into cats, is not a limit to evolution!
  3. 21 June 2016 stevevw: Now you do not need to ignorantly repeat the "most mutations are harmful" myth.
  4. 23 June 2016 stevevw: Papers that do not state there is a limit to evolution are not evidence of limits to evolution.
  5. 23 June 2016 stevevw: Please read and acknowledge the scientific evidence that makes the idea that microevolution does not lead to macroevolution very ignorant.
  6. 23 June 2016 stevevw: The different definitions of species are not evidence of limits to evolution.
  7. 23 June 2016 stevevw: Ignorance about Darwin's original work and evolution should be remedied by learning about evolution. I suggest you start with Wikipedia.
  8. 23 June 2016 stevevw: None of the paper you cited state that most mutations are harmful.
A no go "list of proofs"!!!

There are no transition fossils, not a single one out of billions of fossils discovered.

What does observation show? Real observation without input of bias or conjecture?

You have no transition fossil evidence. Zero.

It is your belief that "Evolution happened".

Have you turned this thread into a stevevw bashing?
 
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Heissonear

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No its saying in most cases when beneficial mutations are added together they incur a fitness cost. So this is supporting what I said in that what can seem like a benefit on its own becomes a negative when mixed with other mutations and multiple mutations are needed to make anything significant in evolution. So mutations together dont build better and fitter life but the opposite. Humans carry many negative mutations that are deteriorating our genomes.

The first problem is whether there is the type of beneficial mutations that lead to increased function, complexity and fitness in the first place. What is cited as a benefit may just be a organism tolerating slightly negative mutations or the change that has brought the perceived benefit is actually negative anyway because it is changing what was already good which will have a cost even if it is that the organism has to use more energy to deal with that change.

For there to be new features and creatures beneficial mutations need to be more than very rare and need to be significant to be selected. Something around zero is not going to be often or great enough and have enough influence especially if its claimed to have created the vast and immense amount of complexity and variety we see in life. But not just that evidence says that no matter if mutations are beneficial, neutral or negative they are a cost to fitness and cannot go beyond certain limits because they are errors that are changing what is already good and working.

Similarly, genetic drift increases the likelihood that a potentially beneficial mutation will be lost before it becomes widespread in the population. The net effect of genetic drift in such populations is "to encourage the fixation of mildly deleterious mutations and discourage the promotion of beneficial mutations,",
The frailty of adaptive hypotheses for the origins of organismal complexity
http://www.pnas.org/content/104/suppl_1/8597.full

You are assuming that because some of the science may say that there is some benefit even if it’s slim pickings it is then saying that this is enough to create all of life. There is a big difference in some possible slightly rare beneficial mutation and there being enough to be a significant benefit that would create the complex variety we see in life.

Slight benefits don’t add up to much and on their own they get lost in the many other mutations that are not benefits. It would take more time then evolution claims to have them build up to all the life we see even if they did hang around and build up slowly according to the evidence, Supporters of darwins theory want to find beneficial mutations and want to elevate them and give them more credit than they have. they have to as this is the only source of all the complex variety we see. But how can a source that is basically damage to the codes that make life produce something better.

In addition, one can just as easily point to a long list of pathologies that can arise from an overly rapid proliferation of a new phenotype, and such scenarios have motivated a completely alternative, and equally speculative, view, that s(election can favor mechanisms that suppress evolvability 103). Furthermore, theoretical studies have shown that the kinds of complexities that are often focused on by those enamored with evolvability (e.g., increased dimensionality and modularity) can actually inhibit the rate of adaptive evolution.

"What is in question is whether natural selection is a necessary or sufficient force to explain the emergence of the genomic and cellular features central to the building of complex organisms."
http://www.pnas.org/content/104/suppl_1/8597.full


The effects of low-impact mutations in digital organisms
"it is important for biologists to realistically appraise what selection can and cannot do under various circumstances. Selection may neither be necessary nor sufficient to explain numerous genomic or cellular features of complex organisms."
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102618/

The difference is I support the idea that life can evolve to a point through tapping into that genetic material and create variations of each type of creature. But if you consider this concept is basically the same for theistic evolution. The only difference is the point at which God has intervened. Whether He places that genetic info and programming into a single celled organism or more complex ones doesn't matter. The instructions for life whether through processes of evolution or non adaptive mechanisms needs the intervention of intelligent agent such as God to make it happen.

Life and the creation of more complex organism doesn't create itself through purely naturalistic processes and come from nothing for which Darwin's theory promotes. Scientific tests show that evolution cannot explain how complex variety can come into existence and continue to be created through a self creating naturalistic process. That is why supporters of evolution are appealing to more and more design capabilities and powers from evolution because much of what we see is beyond the explanations for what Darwin's theory is capable of.

Creationism doesn't use any of this and appeals to purely supernatural creation for all life and believes what we see was all created. They also believe that life and all existence is only a few thousand years old. In some ways supporters of Darwin's Evolution are appealing more to unrealistic powers of creation by speculating that a blind process based on assumption which hasn't been scientifically verified can create everything we see and dogmatically stick to it no matter what.

You are obviously either not reading the papers or ignoring certain parts that are showing the evidence. Look at the above papers for starters which show that beneficial mutations are overcome by other mutations and the effect is not great enough to be selected or gain a foothold to keep adding towards creating complex features. IE,
The net effect of genetic drift in such populations is "to encourage the fixation of mildly deleterious mutations and discourage the promotion of beneficial mutations,",. increased dimensionality and modularity) can actually inhibit the rate of adaptive evolution.

But here are other papers I have posted that say the same
Here, it is argued that random genetic drift can impose a strong barrier to the advancement of molecular refinements by adaptive processes.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503168/

Similarly, genetic drift increases the likelihood that a potentially beneficial mutation will be lost before it becomes widespread in the population.
http://www.ncbi.nlm.nih.gov/pubmed/17494740

Are you serious, I must have posted this evidence 10 times. How can you say that you want me to cite it again? You’re obviously not following the link because you don’t want to make the connection as this will show that I am correct. Here it is again.

The frailty of adaptive hypotheses for the origins of organismal complexity.

Numerous aspects of genomic architecture, gene structure, and developmental pathways are difficult to explain without invoking the nonadaptive forces of genetic drift and mutation.
These issues are examined in the context of the view that the origins of many aspects of biological diversity, from gene-structural embellishments to novelties at the phenotypic level, have roots in nonadaptive processes,

http://www.ncbi.nlm.nih.gov/pubmed/17494740

The evolution of genetic networks by non-adaptive processes
Although numerous investigators assume that the global features of genetic networks are moulded by natural selection, there has been no formal demonstration of the adaptive origin of any genetic network. This Analysis shows that many of the qualitative features of known transcriptional networks can arise readily through the non-adaptive processes of genetic drift, mutation and recombination, raising questions about whether natural selection is necessary or even sufficient for the origin of many aspects of gene-network topologies.
http://www.nature.com/nrg/journal/v8/n10/full/nrg2192.html

How the papers talking about the inability of beneficial mutations to increase complexity.

Ah if you go back and check my posts you will find I have already posted support for this. There is support for this in this post as well in the above papers.

Its not about creationism as stated before. All that I am posting is purely to do with the science as supported by the papers posted. Its about whether evolution through chance random mutations and natural selection can produce the complexity and variety we see in life or whether it is through other sources such as non adaptive ones that use pre existing genetic info.
Excellent post!

It took many years of being an evolutionist before I became open to views you present in this post.
 
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The genetic code to digest nylon didn't exist before the mutation producing nylonase.
Its funny how there are a few repeated examples being used all the time to prove evolution. Another being the antibiotic resistance of bacteria and the fact that the antibiotics were only around in relatively recent times. If this were true there should be ample examples and and not having to hold onto these few examples that are being held up all the time. We should be able to mutate at least the beginning of stages in morphing new features into existing types of creatures such as with fruit flies and maybe adding another feature they havnt got.

But all they do is mutate another set of the same wings or change their shape and size or add some more of the same eyes but maybe in different colors. Normally with these changes the mutated flies are poor examples and are sickly and die and the additional changes are setbacks to fitness rather than an addition that improves them. The changes in bacteria is usually a loss of info that switches an ability off so that it can resist antibiotics or digest nylon and therefore also incurs a cost to fitness and not an addition of new genetic ability that adds fitness.

The other thing is bacteria being micro organisms have a great capacity to share genetic info so between the millions of bacteria there is a great amount of genetic material that can be transferred and tapped into. So it may be a case of using existing genetic info and recombining it. But heres the other point, they have discovered that bacteria were able to gain the ability to become antibiotic resistance thousands of years ago. So it seems they have been able to do it well before antibiotics. The chances are the ability for digesting nylon is also something that has been around for some time and is just being tapped from the preexisting genetic ability of bacteria.

Antibiotic resistance is ancient
http://www.nature.com/nature/journal/v477/n7365/full/nature10388.html

Here is another paper showing that even ancient bacteria 250 million years old is similar to modern bacteria. So it seems that life was very complex early in the scheme of things and has had similar abilities to today's life.
The Paradox of the “Ancient” (250 million year old) Bacterium Which Contains “Modern” Protein-Coding Genes:
“Almost without exception, bacteria isolated from ancient material have proven to closely resemble modern bacteria at both morphological and molecular levels.” Heather Maughan*, C. William Birky Jr., Wayne L. Nicholson, William D. Rosenzweig§ and Russell H. Vreeland ;
http://mbe.oxfordjournals.org/...../19/9/1637
 
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That is an example of totally not understanding a simple yes/no question.
30 June 2016 stevevw: Do humans and chimps have a common ancestor?
I would have thought you got the jist of my reply was stating that I disagreed with humans and apes having a common ancestor by the fact I was saying that mutations have been shown to not be able to produce enough benefit to create new types of creatures and that there are limits to how far you can change our genomes.

Checked and no replies to my 28 June 2016 points about Douglas Axe so they have not been addressed.
I think it may be better to address these one at a time as you seem to be not understanding what I am saying or you are missing what I am saying. You actually made your point about Doug Axe on around the 17/6/16 and I replied then. You are more or less restating your point in the same way so my original reply should have addressed this.
  1. : Douglas Axe discredited his competence by associating with the
    Discovery Institute by being the director of the DI-funded Biologic Institute.
As I stated earlier for which you have ignored if you use the false comparison of Doug Axe being discredited because of his association with the Discovery Institute (which is not a valid and logical argument anyway) then the same logic should apply to him gaining credibility for being associated with the secular science organization and research positions he has held in biology with the University of Cambridge, the Cambridge Medical Research Council Centre, and the Babraham Institute in Cambridge. He should also gain more credibility for his accepted peer reviewed papers by secular mainstream science journals the Journal of Molecular Biology, the Proceedings of the National Academy of Sciences, Plos, and Nature.

But all this is a fallacy as you cant judge a persons academic ability by what they are associated with. As I mentioned earlier which you also ignored some of the great scientists who made great discoveries such as Issac Newton who discovered the theory of Gravity, Max Plank who received a Nobel Prize in physics and is famous for his work in Quantum physics, and Gregor Mendal who is known as the father of modern genetics all believed in God and intelligent design. So with your logic that would discredit all these famous scientists.
  1. : The evidence is that Douglas Axe is not an expert on evolution - he has published 9 paper in 29 years which makes him an expert on nothing (experts publish multiple papers per year!).

Once again I already addressed this when I stated that your logic is false once again. There is no evidence and the evidence you cite is your own personal opinion without any support. Personal opinions dont count as scientific verification. But lets go with the logic of your personal opinions to see how they are fallacies anyway. First Doug Axe has produced more papers then you assert. I have more than 9 myself and I havnt even bothered to do a search for more. You are obviously not including the many he has done with others in collaborations. Secondly how many papers a scientists does is not a good way to determine if they are right or not.

What you are asserting is that if a scientists hasn't done x amount of scientific work or hold certain positions then they are not credible or they do not know what they are talking about which is completely false and ridiculous. Stephen Hawkins had hardly any papers published when he put out his famous paper "Singularities and the Geometry of Space-Time". Albert Einstein developed special relativity while basically unemployed (working in a patent office since he couldn't get a job as a physics professor. So your logic is false and the argument is based on a fallacy.
  1. : At least one of those papers was slightly dubious and wrongly cited by IDiots as evidence against evolution
Axe (2004) and the evolution of enzyme function
It seems you've been reading those anti ID blogs again. Of course you think they are regarded as top shelf scientific support and are not biased. Yet you provide no scientific support for saying that at least one of the papers is just slightly dubious, I'm surprised you have given it so much credit. But you dont specify which paper let alone what particular part you think is dubious or provide any evidence for this claim.

How is it that supporters of evolution can use all sorts of invalid sources for their evidence such as blogs and atheists sites but if anyone who disagreed with evolution and especially anyone who had the slightest connection to anything religious uses the equivalent support for the same reasons there would be cries of invalid evidence. But I sort of guessed which paper you were referring too when you mention it was used against evolution. That being the only one that is connected with someone or something religious which proves my point.

The only problem with that is I purposely placed it with other mainstream papers that actually support that one paper you say is dubious which say the same thing. So when you say that one paper is dubious you are also saying that several different scientists are wrong at the same time. That then becomes a little hard to believe without support. Do I believe your personal opinion or the scientific evidence from several experts in biology who have done scientific testing.
 
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Excellent post!

It took many years of being an evolutionist before I became open to views you present in this post.
Thanks Heissonear and I too went through something similar. But these ideas are not mine and are from scientists who do the research. I am just willing and open to consider all possibilities.
 
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Posts with the ignorance that evolution is breeding, irrelevant links, etc. do not address what I have pointed out:
This is the 2nd half of your post that I will try to reply to. If I only do some of it I will get to the rest later.
  1. : It is a lie to state that dogs and GMO show limits to evolution. They are not examples of evolution. There seems no limit to what we can breed/engineer.
I cant see how you can say this if you know about evolution. Even Darwin used breeding with his pigeons to understand evolution better. It actually caused him to be concerned about some of his ideas because of the difficulties that breeders had at that time as far as the sickness and diseases that breeding had brought. But here is a post from Berkeley.edu which is a popular supporter and educator of evolution. This is what it says about artificial selection.

A process in which humans consciously select for or against particular features in organisms. For example, the human may allow only organisms with the desired feature to reproduce or may provide more resources to the organisms with the desired feature. This process causes evolutionary change in the organism and is analogous to natural selection, only with humans, not nature, doing the selecting.

So it seems even Berkeley.edu states that artificial selection is similar to natural selection which is one of the main mechanisms of evolution.
  1. : The fantasy that we must be able to create new mammal species, e.g. dogs into cats, is not a limit to evolution!
Why would you say that.
  1. : Now you do not need to ignorantly repeat the "most mutations are harmful" myth.
How is it a myth when I am posting scientific support for it.
  1. : Papers that do not state there is a limit to evolution are not evidence of limits to evolution.
So when that paper states that there are limits what do you think they are meaning.IE, Even supporters of evolution acknowledge there are limits to evolution.
Here is one of the papers I posted and even the heading states there are limits.

Evolutionary layering and the limits to cellular perfection

Here, it is argued that random genetic drift can impose a strong barrier to the advancement of molecular refinements by adaptive processes.
The limits to adaptation can be quantified as the magnitude of fitness load resulting from the inability of selection to promote the most advantageous alleles.

What is it about the words "impose a strong barrier to the advancement of molecular refinement" or "the limits to adaptation" dont you understand as being limits to evolution by restricting continued refinements and improvements of the genetic info.
http://www.pnas.org/content/109/46/18851.long

Heres another that clearly states there are limits or restrictions to evolution.
The frailty of adaptive hypotheses for the origins of organismal complexity
Furthermore, theoretical studies have shown that the kinds of complexities that are often focused on by those enamored with evolvability (e.g., increased dimensionality and modularity) can actually inhibit the rate of adaptive evolution.
http://www.pnas.org/content/104/suppl_1/8597.full
To me inhibit the rate of adaptive evolution is clearly saying that evolution is inhibited and inhibit means limit or restrict.
  1. : Please read and acknowledge the scientific evidence that makes the idea that microevolution does not lead to macroevolution very ignorant.
The talk origin site is even stating that the evidence it uses cannot be scientifically verified and tested and is based on observation to prove macroevolution through common ancestry. They say it’s accepted by those who support evolution so therefore it’s true which is basically a circular argument. The other point is that common decent can be applied to design and Gods creation. If there were particular types of creatures designed or created with the codes for building their particular lines of animals then they would be common ancestors as well.

All life is designed on the same genetic code so of course its all going to be linked whether you support evolution, creation or ID. As the Talk origin site states they don’t speculate how the original organism or organisms came about but just that they were the common ancestor. That is no different to creation or design except creation states that God created the original forms or forms of life. There is also evidence that contradicts common ancestry such as the molecular evidence not matching the tree of life evolution has built. Many closely related animals show anomalies in their genetic make ups which distances themselves from each other.

There are many gaps in the fossil records and there are often sudden appearances of complex life followed by a sudden gap and then the reappearance of different complex life which doesn't follow evolution's line of thinking. The transitions they cite have often been contradicted or have many gaps. There are many examples where evolution has cited transitional links between certain animals only to find later that they were actually just variations of the same animal. So they were too quick to fill the gaps of transitions and misinterpreted the evidence.

The problem is much of the evidence for evolution is based on observation which is subjective and open to interpretation. Many people including supporters of evolution for which I have posted only a few examples disagree with each other about those interpretations of what is transitional and what is not. Genetic evidence has come out against evolution in recent years which is the best evidence for proving evolution because its not based on personal interpretations but scientific testing.

The best evidence against macro evolution comes from the many papers I have posted showing that there are limits to how mutations and natural selection can go beyond micro evolution.Evolution uses micro evolution which has been verified through tests and then applies that to macro evolution and assumes the same thing happens. But the tests indicate the opposite so the only other support they can have is observational evidence which is unreliable.
 
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This is the 2nd half of your post that I will try to reply to....
  1. Examples used to understand evolution doe not mean that evolution is dog breeding or genetic engineering as you stated, stevevw.
  2. It is because that is what you states.
  3. It is a myth because it is debunked by the scientific evidence that I provided you. To be more specific it is a myth that is seen from creationists.
  4. Papers that do not state there is a limit to evolution are not evidence that there is a limit to evolution. Stating that they do once is a mistake, twice is an error, more times becomes a lie.
    4 July 2016 stevevw: The phrase "inhibit the rate of evolution" means that evolution goes slower (the rate of) - not that evolution stops.
  5. 29+ Evidences for Macroevolution: "This hypothesis has been verified and corroborated so extensively that it is currently accepted as fact by the overwhelming majority of professional researchers in the biological and geological sciences"
    4 July 2016 stevevw: The Talk Origins site does not state that the evidence for macroevolution cannot be verified
    29+ Evidences for Macroevolution: "It must be stressed that this approach to demonstrating the scientific support for macroevolution is not a circular argument: the truth of macroevolution is not assumed a priori in this discussion. Simply put, the theory of universal common descent, combined with modern biological knowledge, is used to deduce predictions. These predictions are then compared to the real world in order see how the theory fares in light of the observable evidence."
    4 July 2016 stevevw: The invalid assertion that the evidence for macroevolution is circular.
    4 July 2016 stevevw: Parroting the "gaps in the fossil record", "transitional fossil", "Cambrian explosion" creationist claims? Index to Creationist Claims
4 July 2016 stevevw: A fantasy about any (so far imaginary) limits to evolution being evidence against macroevolution - as far as you know the limits may be above the species level :eek:!
  1. 15 June 2016 stevevw: It is a lie to state that dogs and GMO show limits to evolution. They are not examples of evolution. There seems no limit to what we can breed/engineer.
  2. 21 June 2016 stevevw: The fantasy that we must be able to create new mammal species, e.g. dogs into cats, is not a limit to evolution!
  3. 21 June 2016 stevevw: Now you do not need to ignorantly repeat the "most mutations are harmful" myth.
  4. 23 June 2016 stevevw: Papers that do not state there is a limit to evolution are not evidence of limits to evolution.
  5. 23 June 2016 stevevw: Please read and acknowledge the scientific evidence that makes the idea that microevolution does not lead to macroevolution very ignorant.
  6. 23 June 2016 stevevw: The different definitions of species are not evidence of limits to evolution.
  7. 23 June 2016 stevevw: Ignorance about Darwin's original work and evolution should be remedied by learning about evolution. I suggest you start with Wikipedia.
  8. 23 June 2016 stevevw: None of the paper you cited state that most mutations are harmful.
 
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