First, they are not so much principles as fact.
Second, that does not change anything about selfish genes favouring unselfish social behaviour.
Nor does it change anything about human capacity to envision scenarios of the future and be guided by them.
If unselfish social behaviour and thinking about the future helps to preserve and multiply genes, those characteristics will be favoured here and now in a population of selfish genes even though the genes themselves can't deal with tomorrow.
I have no idea what you mean by humans violating these principles. Human evolution is the same process as all other biological evolution. Our genes do not attempt to deal with tomorrow. And we have no conscious control over the activity of our genes. But our genes don't have a lot of control over our thoughts and behaviour either. All they can do is survive, or not. So, if they are more likely to survive in a population that encourages unselfish behaviour, that is the type of behaviour that will be encouraged genetically as well as socially in future generations. Not because genes are planning ahead, but because genes which stimulate empathy, compassion, sharing, etc. are the survivors in a larger and larger proportion of the population over subsequent generations.
All evidence we have of human origins clearly indicates we are indeed products of an evolutionary process.