DOCUMENTS RELEASED BY the National Institutes of Health yesterday raise new questions about government-funded research on viruses conducted in China. The annual grant reports from EcoHealth Alliance, which the NIH sent to The Intercept in response to a lawsuit, provided additional evidence that the U.S. nonprofit — which studies emerging infectious diseases — and its sub-awardee, the Wuhan Institute of Virology, were engaged in risky experiments and that the NIH may not have been fully aware of these activities.
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“Changing the receptor binding site on MERS is sort of crazy,” wrote Jack Nunberg, a virologist and director of the Montana Biotechnology Center at the University of Montana, in an email to The Intercept after reviewing the documents. “Although these new chimeric viruses may retain properties of the MERS-CoV genetic backbone, engineering of a known human pathogen raises new and unpredictable risks beyond those posed by their previously reported studies using a non-pathogenic bat virus backbone.” The researchers’ intent, which some scientists consider integral to defining gain-of-function, remains unclear.
“In the very same report, they showed data that one of their chimeric SARS-like viruses caused more severe disease in a humanized animal model than the original virus,” said Alina Chan, a Boston-based molecular biologist and co-author of the upcoming book “Viral: The Search for the Origin of Covid-19.” “After seeing that result, why did they do similar work using the MERS human pathogen?”
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The work with the MERS virus complicates EcoHealth Alliance’s previous claims that the research covered in the grant had not involved work with “potential pandemic pathogens,” or viruses, bacteria, and microorganisms that carry a likely risk of uncontrollable spread between humans. Kessler had previously told The Intercept that “All the other viruses studied under this grant are bat viruses, not human viruses.” But MERS is known to infect and spread in humans, and was specifically designated under the NIH’s former pause on funding gain-of-function research of concern.
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“This is a pattern of dishonesty,” said Chan, the molecular biologist and “Viral” author. “It should be clear now that we cannot take the word of conflicted parties in the search for the origin of Covid-19,” she added. “It is urgently important that the public and investigators gain full access to all EcoHealth documents relating to research conducted in Wuhan.”
EcoHealth Alliance Conducted Risky Experiments on MERS Virus in China
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“Changing the receptor binding site on MERS is sort of crazy,” wrote Jack Nunberg, a virologist and director of the Montana Biotechnology Center at the University of Montana, in an email to The Intercept after reviewing the documents. “Although these new chimeric viruses may retain properties of the MERS-CoV genetic backbone, engineering of a known human pathogen raises new and unpredictable risks beyond those posed by their previously reported studies using a non-pathogenic bat virus backbone.” The researchers’ intent, which some scientists consider integral to defining gain-of-function, remains unclear.
“In the very same report, they showed data that one of their chimeric SARS-like viruses caused more severe disease in a humanized animal model than the original virus,” said Alina Chan, a Boston-based molecular biologist and co-author of the upcoming book “Viral: The Search for the Origin of Covid-19.” “After seeing that result, why did they do similar work using the MERS human pathogen?”
...
The work with the MERS virus complicates EcoHealth Alliance’s previous claims that the research covered in the grant had not involved work with “potential pandemic pathogens,” or viruses, bacteria, and microorganisms that carry a likely risk of uncontrollable spread between humans. Kessler had previously told The Intercept that “All the other viruses studied under this grant are bat viruses, not human viruses.” But MERS is known to infect and spread in humans, and was specifically designated under the NIH’s former pause on funding gain-of-function research of concern.
...
“This is a pattern of dishonesty,” said Chan, the molecular biologist and “Viral” author. “It should be clear now that we cannot take the word of conflicted parties in the search for the origin of Covid-19,” she added. “It is urgently important that the public and investigators gain full access to all EcoHealth documents relating to research conducted in Wuhan.”
EcoHealth Alliance Conducted Risky Experiments on MERS Virus in China