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The New Retrovirus Thread
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<blockquote data-quote="joshua 1 9" data-source="post: 69518539" data-attributes="member: 376633"><p> <ul> <li data-xf-list-type="ul"><em>“‘It’s a radical concept, one that a lot of scientists aren’t very happy with,’ said Francis S. Collins, director of the National Human Genome Research Institute. ‘But the scientific community is going to have to rethink what genes are, what they do and don’t do, and how the genome’s functional elements have evolved.’<br /> ‘I think we’re all pretty awed by what we’re seeing,’ Collins said. ‘It amounts to a scientific revolution.’<br /> For half a century, the core concept in biology has been that every cell carries within its nucleus a full set of DNA, including genes. Each gene, in turn, holds coded instructions for assembling a particular protein, the stuff that keeps organisms chugging along.<br /> As a result, genes were assigned an almost divine role in biological ‘dogma,’ thought to govern not only such physical characteristics as eye color or hair texture, but even much more complicated characteristics, such as behavior or psychology. Genes were assigned blame for illness. Genes were credited for robust health. Genes were said to be the source of the mutations that underlay evolution.<br /> But the picture now emerging is more complicated, one in which illness, health, and evolutionary change appear to be the work of almost fantastical coordination between genes and swaths of DNA previously written off as junk.<br /> ‘If the surprising amount of RNA transcribed from genomic ‘junk’ proves to be a powerful regulator of genes, understanding it will be critical in the fight against genetic disease, medical researchers predict. A big push is underway, for example, to develop so-called ‘RNA interference’ drugs, designed to turn off gene activity by mimicking the effects of RNA.’<br /> ‘<strong>For medicine, it could be good news if disease is mainly caused by ‘regulators’ ” in the genome, not mutations in genes </strong>themselves,’ said Lander. ‘It suggests that [cures] might be a matter of tweaking the controls – turning them up here, dialing them down there. Nothing about the gene is broken, but the dial may be powered up too high or turned low.’”</em><br /> <a href="http://web.archive.org/web/20150211210749/http://www.boston.com/news/globe/health_science/articles/2007/09/24/dna_unraveled/?page=4" target="_blank">http://www.boston.com/news/globe/health_science/articles/2007/09/<br /> 24/dna_unraveled/?page=4</a></li> </ul></blockquote><p></p>
[QUOTE="joshua 1 9, post: 69518539, member: 376633"] [LIST] [*][I]“‘It’s a radical concept, one that a lot of scientists aren’t very happy with,’ said Francis S. Collins, director of the National Human Genome Research Institute. ‘But the scientific community is going to have to rethink what genes are, what they do and don’t do, and how the genome’s functional elements have evolved.’ ‘I think we’re all pretty awed by what we’re seeing,’ Collins said. ‘It amounts to a scientific revolution.’ For half a century, the core concept in biology has been that every cell carries within its nucleus a full set of DNA, including genes. Each gene, in turn, holds coded instructions for assembling a particular protein, the stuff that keeps organisms chugging along. As a result, genes were assigned an almost divine role in biological ‘dogma,’ thought to govern not only such physical characteristics as eye color or hair texture, but even much more complicated characteristics, such as behavior or psychology. Genes were assigned blame for illness. Genes were credited for robust health. Genes were said to be the source of the mutations that underlay evolution. But the picture now emerging is more complicated, one in which illness, health, and evolutionary change appear to be the work of almost fantastical coordination between genes and swaths of DNA previously written off as junk. ‘If the surprising amount of RNA transcribed from genomic ‘junk’ proves to be a powerful regulator of genes, understanding it will be critical in the fight against genetic disease, medical researchers predict. A big push is underway, for example, to develop so-called ‘RNA interference’ drugs, designed to turn off gene activity by mimicking the effects of RNA.’ ‘[B]For medicine, it could be good news if disease is mainly caused by ‘regulators’ ” in the genome, not mutations in genes [/B]themselves,’ said Lander. ‘It suggests that [cures] might be a matter of tweaking the controls – turning them up here, dialing them down there. Nothing about the gene is broken, but the dial may be powered up too high or turned low.’”[/I] [URL='http://web.archive.org/web/20150211210749/http://www.boston.com/news/globe/health_science/articles/2007/09/24/dna_unraveled/?page=4']http://www.boston.com/news/globe/health_science/articles/2007/09/ 24/dna_unraveled/?page=4[/URL] [/LIST] [/QUOTE]
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