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<blockquote data-quote="mark kennedy" data-source="post: 67190519" data-attributes="member: 29337"><p>It's been a while and this is the first time I've heard this described as '"function" in the human genome according to the evolution-free gospel of ENCODE' (<a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=encode+junk+dna+television" target="_blank">Genome Biol Evol. 2013</a>). It sounds like something I remember seeing emerge a few years back. Basically there are sections of DNA, even gene deserts, where RNA strands can be transcribed and have some kind of functionality. Not everything has to be a protein coding gene, there are regulatory genes and a long list of other RNA based molecular mechanisms in the genome. </p><p></p><p>This link has a fairly interesting Nature video and podcast showcasing some of ENCODE's work:</p><p></p><p style="margin-left: 20px"><a href="http://www.nature.com/news/encode-the-human-encyclopaedia-1.11312" target="_blank">Nature 489, 4648</a> (06 September 2012)</p><p></p><p>The latest publication I can find on them was in 2012:</p><p></p><p style="margin-left: 20px"><a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439153/" target="_blank">An Integrated Encyclopedia of DNA Elements in the Human Genome</a></p><p></p><p>It's always interesting to see these broad sweeps of the genomic landscape, the idea that only a small percentage of the genome was actually functional always seemed grossly absurd to me. I remember back in the 70s we were always being told that 80% of the human brain does nothing, something now known to be false. Since the unveiling of the Initial Sequence of the Human Genome in 2001 we have learned a great deal about alleles and how the genomic landscape can be mapped.</p><p></p><p>The ENCODE project seems limited simply based on it's scope but never underestimate the power of genetics. When the 2001 publication of the Human Genome appeared in Nature everyone else had to adjust to them, something very few scientific disciplines can say definitively. </p><p></p><p>At a glance the effort looks promising and it is certainly a refreshing change from the Darwinian mutation plus selection equals everything rhetoric.</p><p></p><p>Grace and peace,</p><p>Mark</p></blockquote><p></p>
[QUOTE="mark kennedy, post: 67190519, member: 29337"] It's been a while and this is the first time I've heard this described as '"function" in the human genome according to the evolution-free gospel of ENCODE' ([URL="http://www.ncbi.nlm.nih.gov/pubmed/?term=encode+junk+dna+television"]Genome Biol Evol. 2013[/URL]). It sounds like something I remember seeing emerge a few years back. Basically there are sections of DNA, even gene deserts, where RNA strands can be transcribed and have some kind of functionality. Not everything has to be a protein coding gene, there are regulatory genes and a long list of other RNA based molecular mechanisms in the genome. This link has a fairly interesting Nature video and podcast showcasing some of ENCODE's work: [INDENT][URL="http://www.nature.com/news/encode-the-human-encyclopaedia-1.11312"]Nature 489, 4648[/URL] (06 September 2012)[/INDENT] The latest publication I can find on them was in 2012: [INDENT][URL="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439153/"]An Integrated Encyclopedia of DNA Elements in the Human Genome[/URL][/INDENT] It's always interesting to see these broad sweeps of the genomic landscape, the idea that only a small percentage of the genome was actually functional always seemed grossly absurd to me. I remember back in the 70s we were always being told that 80% of the human brain does nothing, something now known to be false. Since the unveiling of the Initial Sequence of the Human Genome in 2001 we have learned a great deal about alleles and how the genomic landscape can be mapped. The ENCODE project seems limited simply based on it's scope but never underestimate the power of genetics. When the 2001 publication of the Human Genome appeared in Nature everyone else had to adjust to them, something very few scientific disciplines can say definitively. At a glance the effort looks promising and it is certainly a refreshing change from the Darwinian mutation plus selection equals everything rhetoric. Grace and peace, Mark [/QUOTE]
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