Nah. Smallpox, like all disease, is a result of Original Sin, which was the fault of Satan and Man. God had nothing to do with it.
I hate to be pedantic... but the "original" settlers were on the North American Continent significantly prior to 1620
Indeed they were. Up until just a decade or so ago, most archaeologists adhered to what is referred to as the "Clovis Model", in vogue since the 1930's. This hypothesis stipulated that the ancestors of Native American peoples came over a land bridge from Siberia about 11,500 years ago during the last Ice Age, thus becoming the "first inhabitants" of North America. Most archaeologists prior to 1990 would dig until they hit the "Clovis horizon" and simply stop, assuming that since there "were no" human inhabitants prior to 11,500 years ago, they would find nothing.
However, archaeologists since then have started digging
below the Clovis horizon, and to their surprise, they have discovered a plethora of remains and objects that vastly pre-date Clovis culture. Dozens of skeletons and artifacts unearthed (or previously unearthed and subsequently re-examined) in North America over the last ten or fifteen years do not fit the Standard Archaeological Template, either being too old for Clovis, or worse, of the wrong archaeoethnic make-up.
The Spirit Caveman, found near Fallon, Nevada, for example, is approximately 9,400 years old, but analysis indicates that he was not Amerindian, but either Caucasian, or possibly Ainu. Kennewick Man, found in 1996 on the Columbia River, dates from 9,500 years ago, and, again, resembles either a Caucasian or an Ainu, or possibly Polynesian. One site in Chile is dated to 12,500 years ago---1,000 years
before anybody is supposed to have walked across the Bering Strait. The Meadowcroft Rockshelter site in Pennsylvania has yielded artifacts that date from 14,000 to 17,000 years old. Another site at Saltville, Virginia, has also rendered artifacts at least 14,000 years old, and the Cactus Hill site, also in Virginia, has yielded spearpoints that are older than 15,000 years ago.
The Topper site on the Savannah River contains artifacts such as tools and spearpoints dating from 12,000 years ago. The kicker is that they do not bear resemblance to similar artifacts constructed by Native American peoples. On the contrary, they are nearly identical to artifacts made by people of the Solutrean culture---which flourished in France and Spain from about 19,000 to 15,000 years ago.
So, whoever was here first, it seems likely that they were not necessarily Native Americans. They very well were probably either Asians, Polynesians, or---jarringly---even Europeans.
Ironic, huh?