"This is the Beginning of the End of the Pandemic" - NJ Hydroxycholoroquine Study a "Game Changer"

[NightHawkeye]

From the "All patients were high-risk", files: "This is the Beginning of the End of the Pandemic" - Dr. Stephen Smith Announces Hydroxy-Choloroquine Study that is "Game Changer" in Battle Against Coronavirus

No patient under 70.

... not a single coronavirus patient under his care who was on the hydroxychloroquine regimen needed to be intibated.
...
"The chance of that occurring by chance according to my sons Elan and Hunter who did some stats for me are .000 something. It’s ridiculously low."​

Thank you Dr. Smith.

 

[Larniavc]

There is a big red flag here.

"....The chance of that occurring by chance according to my sons Elan and Hunter who did some stats for me are .000 something...."

I think we neeed to see the data and statistical inferences made before we come to a conclusion.

 

[NightHawkeye]

There is a big red flag here.

"....The chance of that occurring by chance according to my sons Elan and Hunter who did some stats for me are .000 something...."

I think we neeed to see the data and statistical inferences made before we come to a conclusion.

The data is accumulating quickly. Two French studies completed, a Chinese study in Wuhan completed and now this study. Four studies now (that I know of). How many studies are needed?

Other current studies include a Minnesota study and New York studies currently under way. At this point any study indicating contrary to the already completed studies could be said to be an outlier.

 

[Tanj]

The data is accumulating quickly. Two French studies completed, a Chinese study in Wuhan completed and now this study. Four studies now (that I know of). How many are needed?

Other current studies include a Minnesota study and New York studies currently under way. At this point any study indicating contrary to the already completed studies could be said to be an outlier.

None of these studies are controlled. All of them are anecdotal and don't really tell us anything. Mind you, if I was in a hospital bed with viral pneumonia I'd be demanding they pump me full of the stuff, but you are wrong to say "data is accumulating", and not just because data is a plural of datum so the correct syntax is "data are accumulating". Anecdotes are accumulating. Sadly, the plural of anecdote is not "evidence".

I also would like to see the stats that resulted in 0.000...whatever that even means. The two other issues for me are the inability to spell "intubated", and the fact it's breaking on a cable TV talking head show.

I also have issue with this particular talking head still saying "it's like the flu". Severe seasonal flu in the US kills ~ 70k people in a year, that's ~ 200 people/day. COVID19 was 5x worse than that yesterday, and it's only just getting started.

 

[Mountainmanbob]

Hydroxycholoroquine

I hope they are making a lot of it
enough to be available
to all that need it.

Although prescribed to a few now
put the manufacturing machine on high gear (soon please).

M-Bob

 

[chevyontheriver]

There is a big red flag here.

"....The chance of that occurring by chance according to my sons Elan and Hunter who did some stats for me are .000 something...."

I think we neeed to see the data and statistical inferences made before we come to a conclusion.

But of course. This needs to be published in a peer reviewed journal. And then replicated by other researchers, with carefully controlled studies where some of the folks get placebos, who publish the results in peer reviewed journals. And submitted to the FDA. And studied some more. Two years from now we will be sure. And then it can be rolled out as a treatment. I agree. Except some people will die in the interim.

 

[Dave G.]

No, the studies thus far are a breath of fresh air at least. They are controlled enough for me to want the stuff if I get this bug. But the results I really want to see are the ones where they used hydroxychloriquine and azithramiacin ( excuse spelling) together because this is said to be noticeably more effective than hydroxychloriquine alone.

 

[Basil the Great]

While this news is hopeful, we should still be cautious.

 

[Shrewd Manager]

This one any good to you?

A universal vaccine is disclosed which elicits a protective immune response in different host species and against different coronaviruses.
https://worldwide.espacenet.com/pat...blication/WO9323421A1?q=coronavirus universal

 

[NightHawkeye]

But of course. This needs to be published in a peer reviewed journal. And then replicated by other researchers, with carefully controlled studies where some of the folks get placebos, who publish the results in peer reviewed journals. And submitted to the FDA. And studied some more. Two years from now we will be sure. And then it can be rolled out as a treatment. I agree. Except some people will die in the interim.

Exactly!

 

[Tanj]

This one any good to you?

A universal vaccine is disclosed which elicits a protective immune response in different host species and against different coronaviruses.
https://worldwide.espacenet.com/patent/search/family/025380027/publication/WO9323421A1?q=coronavirus universal

Any good to who? That's a SKB/GSK patent. Unless you think they are in the business of throwing away money, my guess is if it were any good they'd be making it hand over fist.

 

[wing2000]

But of course. This needs to be published in a peer reviewed journal. And then replicated by other researchers, with carefully controlled studies where some of the folks get placebos, who publish the results in peer reviewed journals. And submitted to the FDA. And studied some more. Two years from now we will be sure. And then it can be rolled out as a treatment. I agree. Except some people will die in the interim.

Doctors are administering the drug in hospitals.

 

[rjs330]

This is good news! I hope we increase the use of this stuff. It appears it may be the answer. We however won't know for sure unless we get more use. Holding back may just prolong this disease.

 

[wing2000]

From China, a very small, controlled study of 62 patients with mild symptoms:

The malaria drug hydroxychloroquine helped to speed the recovery of a small number of patients who were mildly ill from the coronavirus, doctors in China reported this week.

Cough, fever and pneumonia went away faster, and the disease seemed less likely to turn severe in people who received hydroxychloroquine than in a comparison group not given the drug. The authors of the report said that the medication was promising, but that more research was needed to clarify how it might work in treating coronavirus disease and to determine the best way to use it.
***
The new study, of 62 patients with an average age of about 45, did have a control group. It was conducted at the Renmin Hospital of Wuhan University, in Wuhan, China. The patients were carefully chosen to exclude people with medical problems that could be made worse by hydroxychloroquine, like abnormal heart rhythms, certain eye diseases, and liver or kidney problems.

***
If the drug is helping, it is not clear how. There are two possible ways. In laboratory studies, it can stop the virus from invading cells. But hydroxychloroquine can also dial back an overactive immune system, which is why it can treat autoimmune diseases. And a powerful immune reaction to the coronavirus is suspected of playing a role in some of the severest cases of the disease.

Malaria Drug Helps Virus Patients Improve, in Small Study

 

[Shrewd Manager]

Any good to who? That's a SKB/GSK patent. Unless you think they are in the business of throwing away money, my guess is if it were any good they'd be making it hand over fist.

Maybe they're too busy laughing at the shipwreck of the footy, who knows?

 

[ZNP]

If the treatment they are using has already been tested and approved for use on humans, though for other diseases, it seems unethical and even a liability issue to withhold it from someone who requests it and then dies.

Also, although anecdotal evidence is not nearly as good as a double blind placebo study, it is still evidence. We should never allow the "best" to become the enemy of the better.

 

[wing2000]

This is good news! I hope we increase the use of this stuff. It appears it may be the answer. We however won't know for sure unless we get more use. Holding back may just prolong this disease.

It should be administered responsibly. And it should be reported responsibly. FOX News (and the op) using the term "game changer" is irresponsible.

The hype has reportedly led to shortages of the drug, depriving people who rely on it for treatment of autoimmune diseases -- lupus, RA and JIA.

[disclosure - my wife suffers from RA and takes this drug- fortunately, we were able to refill her prescription without issue]

 

[sfs]

But of course. This needs to be published in a peer reviewed journal. And then replicated by other researchers, with carefully controlled studies where some of the folks get placebos, who publish the results in peer reviewed journals. And submitted to the FDA. And studied some more. Two years from now we will be sure. And then it can be rolled out as a treatment. I agree. Except some people will die in the interim.

Um, no. We need to have reliable data from good clinical trials. The first trials are already underway, and results will be coming out over the next month or so. Peer review for studies in this space are currently being turned around in two or three days. After that, regulatory approval could be immediate -- it's already been given in the US.

What we want to do is make sure we're not wasting everyone's time on something that doesn't work or even does harm.

 

[Mountainmanbob]

What we want to do is make sure we're not wasting everyone's time on something that doesn't work or even does harm.

It does have side effects but,
give me some anyway if I can't breathe.

M-Bob

 

[timewerx]

But of course. This needs to be published in a peer reviewed journal. And then replicated by other researchers, with carefully controlled studies where some of the folks get placebos, who publish the results in peer reviewed journals. And submitted to the FDA. And studied some more. Two years from now we will be sure. And then it can be rolled out as a treatment. I agree. Except some people will die in the interim.

I'm an inventor in unrelated field and I have to say you're crazy to still be thinking like everything is still normal. Some compromises are needed in crazy times.

You don't have to have a mountain of data to come up with something real.

In another field, I have quite a few game-changing inventions. I succeeded at a lot less cost than others who did the old-fashioned way.

There's a lot of ways highly intelligent people do things quite stupidly and end up wasting a lots of money with very little progress.

Traditional thinking is our #1 enemy. We would have been planting our flags in another planet many light years away in a distant star, 100 years ago if we have not been idolizing traditions.