Iran is different from the Arab nations in the ME. It is more diverse culturally, and many of them trace their sense of patriotism back to Cyrus more than to Muhammad (in fact, Christianity is on the move big time in Iran, albeit under the radar). Like the general says at the end of that video, if any change occurs, it ought to be accomplished by the Iranian people themselves.
That said, a lot of support can be given from the outside. Back in 2009, obama stood by and let the brave Iranians twist in the wind during their tragic "Green Revolution", when we might have been done with the worst regime on Earth for the price of a little moral support. Trump knows this, got us out of the shameful nuke enablement deal and now is putting unprecedented sanctions on Iran, trying to strangle the Mullahs' totalitarian regime. It's working, to the relief of many of the nations of the ME, and I would submit a large reason for the current protests in the streets of Iran is that the people know a different kind of president now sits in the Oval Office.