One of my friend's wives has tried it to great success after she had a child (though she has always been an extremely active, healthy person so that should also be taken into account).
Interestingly enough, there is research being done to see if the Paleo diet can help with autoimmune disorders like MS, Rheumatoid Arthritis and such (by discouraging the growth of gut bacteria that thrive in high gluten diets). My mom has MS and is currently in a study that is looking at this and so far she's had a very promising recovery (from a cane/walker to walking 3 miles a day unaided), so there may be something to it.