A lot of people think that a loss of information is always deleterious. Since creationists refuse to define information. Here’s an example of a loss of genetic pathways that protect the organisms from extreme environmental stressors. These genetic pathways are in animals . Tardigrades only have part of the pathway . The summing up article is from PZMyers website Pharyngula . PZ is an developmental biologist.
Another example using just a single gene is type O blood in humans . The gene that attaches the sugar protein complex responsible for blood type to the red blood cell, is defective . Blood types evolved in great apes in response to blood parasites . ( Humans are great apes)