It is an interesting question where the answers will depend somewhat on one's specific teachings and denominational tradition. My Sunday School and subsequent scriptural teaching adhered to the "historical metaphorical" tradition, in which The Book of Revelations in general and the Four Horsemen of the Apocalypse were specific metaphors invoked by John of Patmos in response to the oppression of the Roman Empire. I still subscribe to the essence of those lessons since the historical and theological evidence has if anything become even more solid over the last century. The Empire at the time (under the rule of Domitian) had become singularly awful even by the standards of its horrid then-recent history, and Christians suffered some of the worst persecution they'd endured. John himself had lost everything he'd worked for and been exiled to Patmos, and for historians familiar with the period, the imagery and references in Revelation have clear parallels to that period of the Roman Empire, with John effectively sending a rousing message of liberation from its oppressive yoke. So to me, the fourth horseman has always been linked to some of the more totalitarian policies of Domitian's time that herded the poor and conscience-driven believers (particularly Christians) into terrible conditions that made them vulnerable to pestilence and death--while at the same time, breaking the authority of the Empire and making the truth and comfort of Jesus' words ever more apparent. Thus I've never been particularly keen about linking any of the Horsemen John described with contemporary events, he clearly had a more specific period (and liberation of people) in mind.
With that said, I won't deny that the general vibe, I suppose one could say, feels eerily apropos right now. I've worked in both medical and military contexts before and seen some horrible things, yet even in my case and for my fellow soldiers, COVID-19 is scaring the living daylights out of us. It really does seem like one of those Biblical scourges but even worse in some of the things it can do. Not sure how much you all have been able to keep up with the latest medical news, but recent findings are showing this coronavirus is far worse than a respiratory disease, it's also doing hideous things to the blood, kidneys, skin, eyes, heart, liver and who knows what else. And even more frightening, we're now finding that it is in fact, doing great harm to kids, has a far higher mortality rate than previously thought (a lot of deaths from things like heart attacks and pulmonary embolisms without pneumonia, are now known to be caused by COVID-19), even the most optimistic doctors are saying even the best vaccines won't work so well and the treatments will be subpar, there's little immunity and it re-infects people, and it spreads even faster and more vigorously than we thought before. I read some old stories about the Spanish flu and plague and there's no doubt those were terrifying. But there's something even scarier about COVID-19 and the range of ways it can hurt you, how insidious it is (it kills or damages tissues sometimes months after infection), the way it's imitating HIV and can hitchhike and spread itself with our modern transportation and technology. So I guess in some ways COVID-19 really is starting to shape up as a kind of literal manifestation of the tribulations in the Scriptures, except even more horrible in its specifics.
