The novel (1,4)-alpha-D-glucan derived from the plant activates the immune system through the activation of macrophages
via TLR6 signaling, NFkappaB translocation and cytokine production.[
32,
105]
Tinospora cordifolia differentially regulate elevation of cytokines as evidenced by the increased production of antiangiogenic agents IL-2 and tissue inhibitor of metalloprotease-1 (TIMP-1) in the B16F10-injected, extract-treated animals. The observed antiangiogenic activity of the plant
T. cordifolia is related to the regulation of the levels of cytokines and growth factors in the blood.[
106] The aqueous extract of
T. cordifolia was found to enhance phagocytosis
in vitro. The aqueous and ethanolic extracts also induced an increase in antibody production
in vivo.[
107]
T. cordifolia extract (TCE) treatment caused significant reduction in eosinophil count and improved hemoglobin in HIV patients.
...
The alcoholic and aqueous extracts of
T. cordifolia are reported to have beneficial effects on the immune system[
81,
87] and have been tested successfully for their immunomodulatory activity.[
97-
103]
ANTIFERTILITY ACTIVITY
Oral administration of 70% methanolic extract of
T. cordifolia stem to male rats at a dose level of 100 mg/d for 60 days did not cause body weight loss but decreased the weight of testes, epididymis, seminal vesicle and ventral prostate in a significant manner
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924974/