In terms of the lose your own soul. Cannot not one simply reverse the equation and come to the same conclusion?
I'm not sure if I'm understanding you correctly. The original though is, "What does it profit a man to gain the whole world, but lose his soul"?
By reversing it, do you mean something like, "What does it profit a man to save his soul, but lose the whole world"?
If that is what you mean, then I would answer with a definitive no, as those are two completely opposing concepts. Think about it this way; let's pretend, hypothetically, that a terrorist has a button which can kill every human on earth. He explains that if you will only acknowledge that Jesus does not have complete authority over the earth, that he himself will not save these people, then, if you do that, he will not press the button and you will save all those people from dying. Would you believe that to be a reasonable bargain?
You could even rationalize that god might reward you for saving all those lives. After all, we're called on to lay our lives down for others. We're called on to love them and go the extra mile for them. All you have to do is say that Jesus doesn't have the power to save them.
Jesus' comment about gaining the world and losing your soul deals with exactly this issue. Your integrity, your personal relationship with God, your loyalty and faithfulness to goodness is more important than the whole world and everything in it.
Yes, it would be sad to see the whole world killed, but that is not your responsibility. You are first and foremost responsible for the choices you make. That is precisely what makes choice and integrity so valuable; no one can ever snatch it away from you. They may kill you, your friends, your family, or even the whole world, but your integrity is something they can never touch,
unless you allow them to.
This is what we must consider even in a situation like abortion. "Hey, I'll save millions of babies; all you have to do is tolerate my hatred, my fear-mongering, my greed, and my bitterness". NO WAY! Nothing is worth selling your soul for.