A mysterious company’s coronavirus papers in top medical journals may be unraveling

NightHawkeye

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From "Chicago and the WHO", files: A mysterious company’s coronavirus papers in top medical journals may be unraveling | AAAS

Surgisphere, which provided patient data for two other high-profile COVID-19 papers, has come under withering online scrutiny from researchers and amateur sleuths. They have pointed out many red flags in the Lancet paper, including the astonishing number of patients involved and details about their demographics and prescribed dosing that seem implausible. “It began to stretch and stretch and stretch credulity.
...
Today, The Lancet issued an Expression of Concern (EOC) saying “important scientific questions have been raised about data” in the paper.
...
The New England Journal of Medicine (NEJM) issued its own EOC about a second study using Surgisphere data.
...
Chicago-based Surgisphere has not publicly released the data underlying the studies.
...
“The whole world thinks now that these drugs are poisonous.”
...
WHO Director-General Tedros Adhanom Ghebreyesus cited the Lancet results in announcing a “temporary pause” in Solidarity’s hydroxychloroquine arm. Regulators in France and the United Kingdom also instructed investigators, including White’s team, to halt enrollment in trials of the malaria drug.
...
The study also reported more deaths in Australian hospitals than the country’s official COVID-19 death statistics
...
“We want to reassure people that the WHO didn’t make any kind of value judgment on the use of hydroxychloroquine.”

But some say WHO had a knee-jerk reaction to a questionable study. “This is a drug that has been used for decades. It’s not like we know nothing about its safety,” says Miguel Hernán, a Harvard epidemiologist and co-investigator on an ongoing trial of hydroxychloroquine in Spain and Latin America for COVID-19 prevention in health care workers
.​

Noting that the AAAS (American Academy for the Advancement of Science) lays claim to being the oldest and largest scientific organization in the world.
 
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essentialsaltes

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Noting that the AAAS (American Academy for the Advancement of Science) lays claim to being the oldest and largest scientific organization in the world.

In the US, probably, but the Royal Society is "the oldest national scientific institution in the world"
 
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sfs

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Note that the WHO has resumed their HCQ trials after determining that there were no safety grounds for stopping them. Also, another study has come out, this time a double-blind study using HCQ to try to prevent COVID-19 in people who have been exposed to it (here). It found no statistically significant effect.
 
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sesquiterpene

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From "Chicago and the WHO", files: A mysterious company’s coronavirus papers in top medical journals may be unraveling | AAAS

Surgisphere, which provided patient data for two other high-profile COVID-19 papers, has come under withering online scrutiny from researchers and amateur sleuths. They have pointed out many red flags in the Lancet paper, including the astonishing number of patients involved and details about their demographics and prescribed dosing that seem implausible. “It began to stretch and stretch and stretch credulity.
...
Today, The Lancet issued an Expression of Concern (EOC) saying “important scientific questions have been raised about data” in the paper.
...
The New England Journal of Medicine (NEJM) issued its own EOC about a second study using Surgisphere data.
...
Chicago-based Surgisphere has not publicly released the data underlying the studies.
...
“The whole world thinks now that these drugs are poisonous.”
...
WHO Director-General Tedros Adhanom Ghebreyesus cited the Lancet results in announcing a “temporary pause” in Solidarity’s hydroxychloroquine arm. Regulators in France and the United Kingdom also instructed investigators, including White’s team, to halt enrollment in trials of the malaria drug.
...
The study also reported more deaths in Australian hospitals than the country’s official COVID-19 death statistics
...
“We want to reassure people that the WHO didn’t make any kind of value judgment on the use of hydroxychloroquine.”

But some say WHO had a knee-jerk reaction to a questionable study. “This is a drug that has been used for decades. It’s not like we know nothing about its safety,” says Miguel Hernán, a Harvard epidemiologist and co-investigator on an ongoing trial of hydroxychloroquine in Spain and Latin America for COVID-19 prevention in health care workers
.​

Noting that the AAAS (American Academy for the Advancement of Science) lays claim to being the oldest and largest scientific organization in the world.
It will be interesting to see how this pans out. There seems to be quite pointed suggestions that the articles are complete fabrications. Some of the reports are a bit suggestive. From the Guardian:
A search of publicly available material suggests several of Surgisphere’s employees have little or no data or scientific background. An employee listed as a science editor appears to be a science fiction author and fantasy artist. Another employee listed as a marketing executive is an adult model and events hostess.
Governments and WHO changed Covid-19 policy based on suspect data from tiny US company
Other sources say that Desai, CEO of Surgisphere, claims to have only 11 employees.
 
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NightHawkeye

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Note that the WHO has resumed their HCQ trials after determining that there were no safety grounds for stopping them. Also, another study has come out, this time a double-blind study using HCQ to try to prevent COVID-19 in people who have been exposed to it (here). It found no statistically significant effect.
Noting that the new study you cite was itself a flawed study by the researcher's own admission.

The researcher admits he couldn't get grant money so he did a quick and dirty study. :doh:
 
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sesquiterpene

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Also, another study has come out, this time a double-blind study using HCQ to try to prevent COVID-19 in people who have been exposed to it (here). It found no statistically significant effect.
The paper says it is only an observational study, with all the weaknesses inherent in such studies.
[edit] it was not blinded
[edit] it was not randomized
 
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sesquiterpene

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For your amusement: when I was searching on this topic earlier this morning DuckDuckGo returned the following for one of the authors of this study:
Mandeep R. Mehra - Wikipedia

Mandeep R. Mehra (born December 1967 in Delhi) is the Head of Data Falsification for the recent Lancet study on Hydroxychloroquine (HCQ).He is the founding medical director of the Brigham Heart and Vascular Center (2012-2019) in Boston, Massachusetts, and specializes in advanced heart failure, mechanical circulatory support and cardiac transplantation.

Apparently this bit of Wikipedia vandalism was repaired within a minute, but was retained by DuckDuckGo.
 
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sfs

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sesquiterpene

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sfs

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The Lancet study based on the Surgisphere data has now been retracted at the request of three of the (four) authors, who said they could no longer vouch for the veracity of their data source. The three were not affiliated with Surgisphere and could not get the company to cooperate with an independent audit of the data.
 
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