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Brazilian Health officials have rejected Russia's Sputnik vaccine, citing contamination issues with replicating adenovirus. The adenovirus vectors Sputnik uses are supposed to be inactive, but it turns out there are some number of infectious ones in each dose. Russia has responded somewhat...

Link:Covid-19: Israel records no daily deaths for the first time in 10 months Israel has been at the forefront in getting vaccines into arms, with the expected result: much less illness and death.

Covid-19 Live Updates: U.S. Recommends J.&J. Shots Restart With Label Noting Rare Clot Risk From the NYT article: and Also, from the Washington Post: https://www.washingtonpost.com/health/2021/04/23/johnson-and-johnson-vaccine-blood-clots/ Edit: Add link to CDC's ACIP 4/23/2021 meeting...

Good news! One Covid vaccine cuts infection rate in all age groups Unlike most countries, the UK prioritized getting at least one dose into arms over getting the full set of two immunizations. To do this, they set the interval between doses at 12 weeks rather than the three weeks used for the...

Headline:Covid-19: US agencies call for pause in Johnson & Johnson vaccine Thread in the Christian-only section: Use of Johnson & Johnson COVID Vaccine is Paused Edit: Add thread here which also discusses this Georgia becomes third state to shut down Johnson & Johnson vaccine site after adverse...

In a study published in the journal Lancet, the Sputnik vaccine showed 91·6% efficacy (95% CI 85·6–95·2) The study included 21 862 participants, all in Moscow, randomized in a 3:1 ratio of vaccinated-placebo. Here's the Kaplan-Meier cumulative incidence curves for the first symptomatic...

J&J's Covid vaccine is 66% effective, a weapon but not a knockout punch Yet another report on clinical trials. This study is much larger than the Novavax one with 44,325 participants, and 468 cases of Covid, giving it much greater statistical power. From the article: and

Novavax COVID-19 Vaccine Demonstrates 89.3% Efficacy in UK Phase 3 Trial | Novavax Inc. - IR Site The results came from an interim analysis of the ongoing clinical trial in the UK, with ~15,000 participants. It is based on only 62 cases of Covid, with 56 in the placebo arm and 6 in the vaccine...

Merck's two candidates flunk out at early Phase I trials when they fail to achieve antibody levels compared to convalescent patients. Both candidates were based on other live vaccines, one measles and the other on VSV (vesicular stomatitis virus, used for a successful Ebola vaccine) Merck...

Fishiness of Piscine Birds Linked to Absence of Poisonous Fungi but not Pizza A spoof article submitted to a predatory publisher.

As expected, the EMA approved the Moderna vaccine for use in the EU. Full approval requires the approval of the EC, expected in the next couple days. Next in line might be the AstraZenica/Oxford vaccine, but the makers of the vaccine haven't yet even requested approval - nor AFAIK in the US...

Hopefully the first of many: WHO issues its first emergency use validation for a COVID-19 vaccine and emphasizes need for equitable global access

The EMA has approved the Pfizer/BioNTech vaccine. There are two more steps in the process. The European Commission needs to approve (expected late Monday), then each individual country also need to approve. Germany has said that it hopes to start vaccinating Dec. 17th. Covid: Regulator...

After receiving Moderna's experimental Covid mRNA vaccine in a clinical trial, a 72-year old man was struck by lightning and survived, thus demonstrating the vaccines remarkable protective power. https://www.fda.gov/media/144434/download

Covid: US approves Moderna as second vaccine Things are looking up, but against a backdrop of increasing infections and deaths.

I think it was unanimous with one abstention - I was a bit busy so I don't have an actual tally, but there weren't any no votes. The discussion was quite a bit better than last week's, probably because of less tensions than the Pfizer precedent involved. There really was no doubt - given the...

Great news! We finally have a vaccine, and I fully expect a second one (Moderna) in a week. Note that this is an EAU (Emergency Use Authorization) and not a full approval. FDA Takes Key Action in Fight Against COVID-19 By Issuing Emergency Use Authorization for First COVID-19 Vaccine Edit...

While two vaccines for Covid19 (Pfizer/BioNTech and Moderna) will likely be approved in the US in the next couple weeks, two among the other 100+ candidates have received setbacks. Development of one by CSL and the University of Queensland has been halted completely, due to it creating false...

The Question before the committee was The final tally was 17 yes, 4 no, and one abstention. I watched most of the eight hour meeting. I think most of the no votes were concerned about the inclusion of the 16 to 17 year olds, because they are technically minors (?) and they represented a small...

The FDA released briefing documents for it's Dec. 10 meeting to discuss EUA for the Pfizer Covid19 vaccine, 55 pages for those wanting to look in detail at the ongoing study. VRBPAC December 10, 2020 Meeting Announcement Here's the money shot, vaccinated in blue, placebo in red. Note that the...