If we are going on past actions of the government then we all have reasons to be concerned. Minorities, prisoners, government employees, mental patients, etc. have been subject to government abuses in regards to informed consent.
A. MKULTRA - During MK Ultra the government conducted experiments on mental patients, at least one of its own employees resulting in death, other citizens, etc.
Wikipedia page on MKultra for an overview of the topic
Project MKUltra - Wikipedia
SF weekly article which discusses operations in San Francisco where agents lured men with prostitutes then drugged them, as well as drugging people at bars, restaurants, and other locations
Operation Midnight Climax: How the CIA Dosed S.F. Citizens with LSD
Notes from the Joint Hearing before the Select Committee on Intelligence and the Sub-committee on Health and Scientific Research in 1977. The document spells out that experiments were performed on unwitting subjects, and lists a number of details
http://www.nytimes.com/packages/pdf/national/13inmate_ProjectMKULTRA.pdf
Memoranda related to the death of Dr. Frank A. Olson, as a result of an MKUltra experiment
http://www.voltairenet.org/IMG/pdf/olson_documents.pdf
A PDF copy of a 1977 New York Times article spelling out funding of experiments in private institutions. It is based on the discovered remaining documents, and interviews
https://mikemcclaughry.files.wordpr...to-control-behavior-ny-time-august-2-1977.pdf
B. Forced sterilization - The government sterilized those they deemed feebly minded, native Americans, blacks, Puerto Rican women, etc.
Wikipedia page on forced sterilization for an overview of the topic
Compulsory sterilization - Wikipedia
The majority decision of the United States Supreme Court in the case of Buck vs. Bell, in 1927, upholding sterilization for those deemed "feeble minded." Hosted by Cornell Law School
BUCK v. BELL, Superintendent of State Colony Epileptics and Feeble Minded.
CNN and MSNBC articles discuss reparations for survivors of North Carolina's sterilization program
North Carolina lawmakers OK payments for victims of forced sterilization | CNN
For eugenic sterilization victims, belated justice
CNN article discusses California's program which sterilized 20,000 people
California's dark legacy of forced sterilizations | CNN
Psychology Today article discusses the historical impact of sterilization, and notes cases where it continues today
https://www.psychologytoday.com/blo...201309/involuntary-sterilization-then-and-now
Jstor article recounts the sterilization of native-american populations in the United States, primarily by the Indian Health Services
The Little-Known History of the Forced Sterilization of Native American Women - JSTOR Daily
C. Sexually Transmitted Disease studies in Guatamala
From 1946-1948 United States Public Health Service studies were taking place in Guatemala, where the unknowing subjects (prisoners, mental health patients) were unwittingly, intentionally, exposed to sexually transmitted diseases. Unlike the Tuskegee study where those who already had syphilis were denied treatment, in this case the subjects were intentionally infected, and then given treatment to see what treatments would work. Some were not treated at all.
CNN article describing experiment in a US prison in which inmates were injected with gonorrhea, and later experiments in Guatemala with sexually transmitted disease, carried out without consent
Studies show 'dark chapter' of medical research - CNN.com
United States government apologizes for unethical experiments in Guatamala
US apologizes for infecting Guatemalans with STDs in the 1940s - CNN.com
Center for Disease Control summary of the Guatemalan study, which indicates that initial experiments involved infected female sex workers being intentionally used to transmit disease to prisoners. Soldiers and patients in mental hospitals were also subjects in the study
Fact Sheet on the 1946-1948 U.S. Public Health Service Sexually Transmitted Diseases (STD) Inoculation Study | HHS.gov
Lessons learned regarding informed consent, especially when the United States Government is concerned, have been costly. We should not just brush over informed consent.