US agencies call for pause in Johnson & Johnson vaccine

sesquiterpene

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Headline:Covid-19: US agencies call for pause in Johnson & Johnson vaccine

Thread in the Christian-only section:
Use of Johnson & Johnson COVID Vaccine is Paused
Edit: Add thread here which also discusses this
Georgia becomes third state to shut down Johnson & Johnson vaccine site after adverse reactions

A rare but possibly fatal side effect that has plagued the AstraZenica/Oxford vaccine has now been reported for the J & J vaccine. Both of these vaccines use an inactivated adenovirus to deliver the spike protein, although they use different strains of the virus. This side effect has not shown up in the two mRNA vaccines, Pfizer/BioNTech and Moderna.

The side effect, called cerebral venous sinus thrombosis (CVST), has appeared in only 6 of the ~7 million people who have received the J & J vaccine, but for the AstraZenica/Oxford vaccine it appears to be around 1 in 200,000. Vaccination with the AstraZenica vaccine was temporarily paused in Europe but has resumed, with some countries restricting it's use to older adults who appear to be at less risk for the side effect.

A cost/benefit calculation based on the AstraZenica vaccine is shown here, based on a high exposure risk (possibly equivalent to what Michigan is experiencing now). There are other calculations hereWinton Centre Cambridge
AZ_harms-benefits_high_exposure_8-4-21.width-800.png
 
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sesquiterpene

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Jimmy D

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It probably depends on which country, as the risk changes with age, and countries differed on which age cohort they were vaccinating. There's some discussion of that here, and at other blog posts on the same site:
https://blogs.sciencemag.org/pipeline/archives/2021/04/12/az-oxford-calculations

Im not trying to argue with you, but your first article estimates the risk at approximately 1 in a million for the Az vaccine. I only mention it because the figures you quote make it seem a lot more dangerous than the figures we’re being told in the media over here. I wouldn’t want anyone to be put off getting vaccinated by inaccurate information.

Do I remember correctly that you are a scientist? I apologise if I’m “teaching you to suck eggs”.
 
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sesquiterpene

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Im not trying to argue with you, but your first article estimates the risk at approximately 1 in a million for the Az vaccine. I only mention it because the figures you quote make it seem a lot more dangerous than the figures we’re being told in the media over here. I wouldn’t want anyone to be put off getting vaccinated by inaccurate information.

Do I remember correctly that you are a scientist? I apologise if I’m “teaching you to suck eggs”.
Yes, I don't know what the actual risk is(edit: and which risk one is talking about - the BBC mentioned fatal blood clots, the infographic "blood clots", and I think the FDA was only mentioning cases, with one fatality) - it's low enough that it's hard to get good statistics, and it will probably take months to firm up the numbers. The infographic I posted seems to imply a risk higher than one in a million. I was actually thinking that the J & J numbers will probably trend towards higher risk, similar to the what the infographic showed for the Az.

And the BBC article only stated that it "has been estimated" without attribution. I'm sure that a wide range of estimates are available.
 
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dqhall

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Im not trying to argue with you, but your first article estimates the risk at approximately 1 in a million for the Az vaccine. I only mention it because the figures you quote make it seem a lot more dangerous than the figures we’re being told in the media over here. I wouldn’t want anyone to be put off getting vaccinated by inaccurate information.

Do I remember correctly that you are a scientist? I apologise if I’m “teaching you to suck eggs”.
One in a million risk of lung blood clots with the JNJ vaccine. There have been six or seven cases.

The problem is 476 died of COVID in a day. The seven day average hospitalization count is over 5,000. This is like killing and giving hospital bills to many without proof the vaccine caused damage anywhere near the damage caused by withholding vaccine from vaccination sites.
 
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sfs

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"At the time of writing, Norway has reported a rate of 1 in every 25,000 doses, Germany reported 1 in 100,000 doses, while Europe’s overall figures are 1 in 210,000. The UK has reported about 1 in 500,000 doses. Specifically, 169 reported cases of cerebral venous sinus thrombosis (CVST) and 53 cases of splanchnic vein thrombosis were reported in 34 million vaccine recipients in the UK and European Economic Area as of time of writing this document."
From https://www.un.org/sites/un2.un.org/files/coronavirus_vipitguidance.pdf
 
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Danthemailman

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Federal health agencies on Tuesday called for a pause on administering the Johnson & Johnson vaccine to dig deeper into reports from six women between the ages of 18 and 48 who said they fell ill with a "a rare and severe type of blood clot" – as described by the CDC – within two weeks of receiving the vaccine. Only one woman has died so far.

CDC investigating death possibly connected to Johnson & Johnson vaccine
 
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trophy33

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EU Commission to end AstraZeneca and J&J vaccine contracts at expiry - reuters.com

“The European Commission, in agreement with the leaders of many (EU) countries, has decided that the contracts with the companies that produce (viral vector) vaccines that are valid for the current year will not be renewed at their expiry,” the newspaper reported.

It added that Brussels would rather focus on COVID-19 vaccines using messenger RNA (mRNA) technology, such as Pfizer’s and Moderna’s.
 
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wing2000

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I think they are being intentionally over cautious because there is already a lot of distrust of these vaccinations, but 1 in a million people getting these blood clots seems to me to be a acceptable tradeoff.

...from the Monday evening WH conference call with US health officials...

Initially, some suggested the government could just issue a warning to consumers and doctors. They didn’t want to undermine confidence in vaccines given the danger of covid-19. But as they talked, two big worries emerged. They feared there might be additional cases of brain blood clots they didn’t know about. And what if the government didn’t act quickly, and as a result more people got the wrong diagnosis and treatment and were hurt or died?

https://www.washingtonpost.com/health/2021/04/13/why-johnson-johnson-vaccine-paused/

It's a tough call to make....
 
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sesquiterpene

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The CDC's Advisory Committee on Immunization Practices- ACIP will meet from 1:30 to 4:30 today to discuss these issues. Link to the livestream:
Advisory Committee on Immunization Practices- ACIP
The ACIP has punted: they are not making any decisions at this time.

My impression was that this was due to the fact that this side effect seems to occur within 14 days of being vaccinated, but only half of the ~ 7,000,000 people who have been vaccinated with the J&J vaccine fall into this range. There should be much better data available in two weeks. The ACIP should be meeting again much more frequently to review incoming data, but no schedules have been set.
 
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