DNA Translation Catch-22

lucaspa

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Originally posted by s0uljah
The obvious conclusion is that both the DNA and proteins must have been functional from the beginning, otherwise life could not exist.

http://www.answersingenesis.org/docs/3974.asp

When you do one of these quotes, you always have to check later research to see if the quote is still accurate. Remember, science changes as new knowledge is added. Popper made these remarks in what? the 1950's or early 1960s?  A lot of work has been done since then. For instance, the ribosomal RNAs are not coded by the DNA.  Yet by themselves they are able to synthesize new proteins:

7.  P S Chimmel and R Alexander, All you need is RNA.  Science 281:658-659, Jul. 31, 1998.  Describes research showing that RNA in ribosomes sufficient to make proteins. Intermediate step in going from abiogenesis to genetic code.

As my note indicates, this gives one set of intermediates.

But there is worse for those thinking that Darwinian selection can't yield the protein synthesis process we see today:

9.  AM Poole, DC Jeffares, D Penney, The path from the RNA world.  J. Molecular Evolution 46: 1-17, 1998.  Describes Darwinian step-by-step for evolution from RNA molecules to cells with directed protein synthesis. All intermediate steps are useful.

Now, as long as this is possible, your claim is falsified.  You don't need a setup manufactured by an outside intelligence.
 
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lucaspa

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Originally posted by JesusServant
Is it not well documented that for DNA to exist that you must have enzymes?  And to have enzymes you must have DNA? 

Sorry, but not quite.  RNA, the precursor to DNA, also acts as an enzyme. Proteins formed by thermal polymerization also function as enzymes and spontaneously form cells.  And some of those enzymes catalyze the synthesis of RNA or DNA.
JR Jungck and SW Fox, Synthesis of oligonucleotides by proteinoid microspheres acting on ATP.  Naturwissenschaften, 60: 425-427, 1973.

So now you have both ends of your "conundrum" and it is no longer a conundrum.

See the thread Protocells: life from non-life.

I'm sorry guys, but abiogenesis simply isn't a gap any longer that you can insert deity into.

 
 
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lucaspa

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Originally posted by JesusServant
Self-replicating is far from self-conceiving though.  And for you, I return a hint:  Check out the Bible and try seeking God, there really is something to it 

Random formation by thermal condensation of amino acids will fulfill the "self-conceiving" part. 

You should not attempt to tie the existence of God to a supposed "gap" in scientific knowledge.  God-of-the-gaps theology has been completely rejected by Christian theologians.  Don't you guys know anything about your own theology?
 
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lucaspa

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Originally posted by JesusServant
Weird how few scientifically minded people posted in this thread.


 :( You really need to wait for the "scientifically minded" to sign on and find the thread.  Just because you don't get an answer in a forum doesn't mean an answer doesn't exist. 

Remember, whenever you have a scientific question such as this one about abiogenesis and guided protein synthesis, first do your own search at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed

Then, after you have done the search, claim --if you still can-- that such knowledge doesn't exist.
 
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JesusServant

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Originally posted by lucaspa
I'm sorry guys, but abiogenesis simply isn't a gap any longer that you can insert deity into.

 

No one said it is proof of God, we will NEVER have physical proof of God.  If God wanted it that way, we'd have it.

And saying "don't you guys know anything about your own theology" just shows how conceited and condescending you are.  If I only went by what man led me to believe, I may believe we turn into angels and fly to heaven when we die too, but just because someone calls something a name, does not make said object, said name.  That's the great thing about clinging onto science like a blankee, if it's refuted or wrong, it can just be changed to be right later on and that's okay. :)
 
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JesusServant

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Originally posted by lucaspa
 :( You really need to wait for the "scientifically minded" to sign on and find the thread.  

I'm sorry, I did not realize how scientifically superior you are to livefreeordie and Jerry Smith and others.  :bow:
 
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lucaspa

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Originally posted by JesusServant No one said it is proof of God, we will NEVER have physical proof of God.  If God wanted it that way, we'd have it.

That's disingenuous at best. The AiG website documenting the "failures" of abiogenesis ends with this: Isaiah 66:2  For all those things hath mine hand made, and all those things have been, saith the LORD: but to this man will I look, even to him that is poor and of a contrite spirit, and trembleth at my word.

You are also ignoring the "two-model aproach" that both ICR and AiG use. Any evidence against evolution is evidence for creationism.  God made the system because it could not have evolved. 

And saying "don't you guys know anything about your own theology" just shows how conceited and condescending you are. 

Perhaps I am. Or frustrated watching you destroy your own theology.  Of course, labeling me conceited and condescending is not showing me to be wrong.  Are you saying that god-of-the-gaps theology is acceptable to Christianity? If so, then why do all Christian theologians outside creationism deplore it so? And declare it unBiblical?

The greatest danger to Christianity is creationism.  Why? Because it sets the theological statements of Christianity up to be falsified by tying them to testable statements about the physical universe. 

That's the great thing about clinging onto science like a blankee, if it's refuted or wrong, it can just be changed to be right later on and that's okay.

Yes, theories can and must change in the face of new data.  Your smiley at the end of your post indicates that you think this attribute silly.  But tell me, wasn't Judaism supposed to change when the new "data" of Yeshu's life, death, and resurrection came along? And what do you think of those people who did not change when Judaism was, to you, refuted?

What you think of as a weakness is actually a strength for anyone seeking truth: scientist or theologian.
 
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lucaspa

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Originally posted by JesusServant
I'm sorry, I did not realize how scientifically superior you are to livefreeordie and Jerry Smith and others.  

Nice try to duck. What you were lamenting in your post was the lack of scientific data on the "conundrum" you posed. So you baited the evolutionists on the board. Well, I gave you the answer to your supposed conundrum, including the references to the specific papers with the specific data. And I also baited you back.  Sauce for the goose.

Do you address the data or admit that your conundrum is solved? Nope, you attack my character. That's fine.  Go ahead.  It won't disguise that your "conundrum" has been answered and that you were arguing ad ignoratum.
 
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I'm sorry, I did not realize how scientifically superior you are to livefreeordie and Jerry Smith and others.

It most likely is the case where it comes to me. I can't speak for livefreeordie and others, but I am a scientific enthusiast, not a scientist. If I have remembered earlier marks correctly, lucaspa is a working scientist.

I don't take offense to the slight from him - after all, it was to your remarks (that were actually directed at lfod, myself, and others - to the effect that none of us were at all scientifically minded) that sparked his reply..
 
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Don't you guys know anything about your own theology?

Ok, if Jerry is right, and you are a working scientist, then you should feel confident in your ability to refute our layman assertions about science. If that is the case, why do you feel so threatened by the article (from another scientist) that you need to insult us?

This thread was going fine until you started in with the attitude. Whats up with that?
 
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Here is the author's comments on the RNA comeback:

To avoid this conclusion, some evolutionists have theorised that one type of molecule could perform both catalytic and reproductive roles. A recent discovery of some catalytic functions in RNA has led many evolutionists to postulate an ‘RNA world’. The idea is that the first life consisted mainly of RNA, which could not only reproduce but also carry out many of the functions now carried out by enzymes. But this model has several dubious postulates:

A pool of exclusively ‘right-handed’ ribose molecules could be produced, separated from a jumble of other sugars, and remain stable long enough; the bases could be produced in large quantities; and a high concentration of phosphate (PO43-) would be in solution rather than precipitated out.

Ribose could combine with the bases and phosphate to produce b-D-ribonucleotides.

These b-D-ribonucleotides could spontaneously produce RNA polymers of the proper form.

That if such polymers form, they could replicate themselves.

That such self-replicating RNA molecules would have all the functions needed to sustain an organism.

That such an RNA organism could give rise to a modern organism with protein catalysts, coded on the reproducing material, and the means to decode them.

These postulates are all contrary to experimental evidence. It is no wonder that one of the leading researchers into ‘RNA World’ models, Gerald Joyce, wrote:

The most reasonable assumption is that life did not start with RNA .... The transition to an RNA world, like the origins of life in general, is fraught with uncertainty and is plagued by a lack of experimental data.
 
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notto

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Originally posted by s0uljah

These postulates are all contrary to experimental evidence. It is no wonder that one of the leading researchers into ‘RNA World’ models, Gerald Joyce, wrote:

The most reasonable assumption is that life did not start with RNA .... The transition to an RNA world, like the origins of life in general, is fraught with uncertainty and is plagued by a lack of experimental data.

Nice out of context quotemine (from 15 years ago). I guess you didn't read his bio. Obviously he is working to fill the lack of experimental data. This lack of data is being addresse and does not constitute any kind of support for the contrary position. The quote simply states the fact that there was at the current time a lack of data in this area. It does not imply that this data will not or has not been collected.

http://www.scripps.edu/phd/biograd/facbio.phtml?tsri_id=1160

"Research Focus
Directed Evolution of RNA and DNA Enzymes
My research concerns the biochemistry of RNA and the development of novel RNA and DNA enzymes through in vitro evolution. Like their protein counterparts, nucleic acid enzymes assume a well-defined structure that is responsible for their catalytic activity. Unlike proteins, however, nucleic acids are genetic molecules that can be amplified and mutated in the test tube. The members of my laboratory and I have learned to exploit the dual role of nucleic acids as both catalyst and genetic molecule to develop RNA- and DNA-based evolving systems that operate entirely in vitro. At best, we can carry out 100 "generations" of test-tube evolution in a day, employing a population of one hundred trillion nucleic acid molecules. This allows us to evolve nucleic acid enzymes far more rapidly than whole organisms evolve in nature.

Our studies of RNA-based evolution are relevant to understanding the early history of life on Earth. It is believed that an RNA-based genetic system, termed the "RNA world", preceded the DNA and protein-based genetic system that has existed for the past 3.5 billion years. Our research aims to recapitulate the biochemistry of the RNA world in the laboratory. We are using in vitro evolution to explore the catalytic potential of RNA, and especially to search for RNA enzymes that have the ability to catalyze their own replication."


Lets read a more recent abstract from Dr. Joyces recent (2002) article on RNA from Nature (the same publicatin the original out of context quote came from in 1989) - if anyone has access to the full article, perhaps you could share soom of it with us.

The antiquity of RNA-based evolution

GERALD F. JOYCE

Departments of Chemistry and Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA (e-mail: gjoyce@scripps.edu)

All life that is known to exist on Earth today and all life for which there is evidence in the geological record seems to be of the same form — one based on DNA genomes and protein enzymes. Yet there are strong reasons to conclude that DNA- and protein-based life was preceded by a simpler life form based primarily on RNA. This earlier era is referred to as the 'RNA world', during which the genetic information resided in the sequence of RNA molecules and the phenotype derived from the catalytic properties of RNA.
 
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JesusServant

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Originally posted by lucaspa
Nice try to duck. What you were lamenting in your post was the lack of scientific data on the "conundrum" you posed. So you baited the evolutionists on the board. Well, I gave you the answer to your supposed conundrum, including the references to the specific papers with the specific data. And I also baited you back.  Sauce for the goose.

Do you address the data or admit that your conundrum is solved? Nope, you attack my character. That's fine.  Go ahead.  It won't disguise that your "conundrum" has been answered and that you were arguing ad ignoratum.

I still don't feel satisified with the answer.  This, to me, has nothing to do with "proving God" though regardless how one track minded you are on it.  Science runs into many problems explaining many theories yet people hold on to them like they're gospel because it gives them an excuse to say goddidntdoit.
 
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notto

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Originally posted by JesusServant
I still don't feel satisified with the answer.  This, to me, has nothing to do with "proving God" though regardless how one track minded you are on it.  Science runs into many problems explaining many theories yet people hold on to them like they're gospel because it gives them an excuse to say goddidntdoit.

At what point do you suggest scientists stop looking and say "goddidit"?

They keep digging deeper because that is their charge. They gather data, interpret the data, and refine their (our?) knowledge and understanding.

Should scientists stop looking for the unknown causes of diseases? Should they stop trying to understand weather?

Your statement does not represent the reason scientists investigate.

Remember, there are many Christian scientists (as well as from other religions). Their work does not hinder their faith. (and in many instances, strengthens it).
 
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LewisWildermuth

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Originally posted by JesusServant
I still don't feel satisified with the answer.  This, to me, has nothing to do with "proving God" though regardless how one track minded you are on it.  Science runs into many problems explaining many theories yet people hold on to them like they're gospel because it gives them an excuse to say goddidntdoit.

Science doesn't give a hoot about how you or anyone else "feels" about an answer. I'm sorry if it wasn't the mystery and science stumping item you wanted.

The answers given you were not about disproving God either. Science is not about that, it is about data and how stuff happens. Science can never disprove God, but it cannot prove God either.
 
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Let's recap this thread. In order to demonstrate the "impossibility" of abiogenesis, a false "conundrum" was proposed that showed that DNA depended on complex proteins for catalysis, and that therefore we should jump to the conclusion that these must have both existed from the beginning. In short, the idea was to convince us that in order for life to have come from non-life by natural means, both complex chemicals must have assembled by chance simultaneously and in close proximity to on another.

The error in jumping to this conclusion was pointed out: that DNA may have evolved after the first living things, which may have relied on self-transcription. Until it is demonstrated that this is not a possibility (a feat that shows no sign of being accomplished soon), then we have conveniently ignored this possibility in order to jump more expediently to our conclusion.

Having been given this answer, instead of acknowledging the mistake, we are now siezing on one hypothetical model of the sort that corresponds to the possibility that life evolved before DNA and to expose the appearance of weakness in it. So what are the weaknesses?

We are not clear on that. Apparently, among other things, the RNA world hypothesis requires that:

A pool of exclusively ‘right-handed’ ribose molecules could be produced, separated from a jumble of other sugars, and remain stable long enough; the bases could be produced in large quantities; and a high concentration of phosphate (PO43-) would be in solution rather than precipitated out.

But no indication of why AiG thinks this is required is given. Why, for instance, does the pool have to be comprised of right-handed ribose molecules, and not both right- and left- handed ribose molecules? Why must they be separated from other sugar molecules in the pool?

etc... etc...

Doubtlessly, there is some reason why this is suggested - but if we are to continue checking AiG's shoddy work (and obviously it requires checking - it was they who suggested that DNA/protein interdependancy should cause us to jump incorrectly to the first conclusion in this thread) - they must explain themselves so that we can properly evaluate whether these problems are critical and insurmountable or whether these problems are solvable... I suppose they want us to assume they are critical and insurmountable so that we will reject the RNA world hypothesis, ignore the fact that we have not eliminated all other possibilities for abiogenesis before DNA, and therefore jump, once again, incorrectly, to the original conclusion. Unfortunately it is not so easy.

They try to convince us with a quote 15 years out of date, and perhaps out of context. I won't be convinced with that. Obviously (based on the more recent quote from the same scientist that Notto posted) the objections from 15 years ago were not critical and insurmountable. If Joyce was not convinced that they were when he wrote those words, why should we be convinced of that now?
 
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notto

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Actually, I think a better question would be to AIG.

"Why do they think a quote that states that there is not enough data to make a conclusion supports their making a conclusion?"

They try to make it sound as if Joyce is saying that the data supports their conclusion but the context of the quote makes it clear that he is stating that there is not enough evidence (at that point 15 years ago) to make a solid conclusion.

Of course, a lot has changed in the last 15 years around RNA research. I think it is a bad choice that AIG STILL uses that quote to try to persuade their audience.

It would be interesting if AIG would use some newer quotes (and newer papers) from Joyce to try to continue to support their position.

I would also be very interested in what content the clipped with the elipses (. ..) from the original quote. Unfortunately, it is not availble online.
 
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