There do appear to be limitations to what we can ultimately comprehend.
As a poster above has indicated, our brains (while significantly more advanced than that of other species) is limited not only by both the number of neurons and their synaptic connections, but is also limited in time and space, implying that our cognitive capacities, including our ability to comprehend all things, is limited by the same factors, to a degree. In addition to this, our senses are limited to a mere five of all the possible sensory data in the universe (presumably because those five within their respective thresholds are all that we really require to survive). Much of our perception of the world is not necessarily reflective of reality in the purest sense, but is a personal process, involving considerable construction occurring as a result of our brain filling in the gaps - hence we experience sensory illusions. We aren't even aware of much of the data that we really do process; it does not enter our immediate attention since it is not relevant to our immediate needs or wants and would simply crowd a short term memory which is itself limited to a mere 15-20 seconds and 7-9 bits of information at a time (without rehearsal). Comprehending the infinite and all that is would seemingly require an equally infinite capacity to do so.
Given the temporal nature of our cerebral matter and the finite capacity of our psyche, it seems highly unlikely that the finite mind shall ever come to full and perfect knowledge of the infinite in its infinity.
That is not to say, however, that our knowledge of ourselves and the universe will not greatly expand in the future as it has accelerated since the past. Our theories of what is behind the ticking of the universe will continue to go on, becoming weirder, more refined and elegant... but an infinite knowledge of the infinite all? Perhaps not in our present state of the human condition - which has been the source of strength for our learning thus far, and yet simultaneously the limitation of our incapacity to know it all.
Given that this is a philosophy board, and philosophy does mean 'love of wisdom', I would suggest that wisdom comes from acknowledging one's own limitations.