Hi james,
Read your OP and just thought I'd offer a secondary explanation for Isaiah's words that he wrote at the direction of the Holy Spirit.
I think it worth keeping in mind, whenever we are reading the Scriptures, 'who' God is talking to and 'who' He is referencing. The old covenant writings are basically historical in nature. They tell us how God has, throughout the existence of His creation, related to His creation. While we can certainly gain understanding of God's nature in understanding much of what we find in the old covenant, I'm not particularly convinced by some of this 'new age' thinking that every word of God is meant to be taken as applying to me, or today's believers in general.
My take on this particular passage that you have referenced in Isaiah, is that these words were spoken through God's prophet, to the people of Israel. God was saying that Israel's watchmen were ignorant and dogs. We, having now the luxury of knowing how the continuing history of Israel worked out, can see that God was absolutely right about this. Israel, as a nation, was not prepared, nor did they understand when Messiah visited them. Israel was God's 'watchmen' in the days of Isaiah. Even David wrote in his prophecy of the day of Jesus' death that 'dogs have surrounded' him.
So, while I also agree that surely most of the people of the world are ignorant, in their understanding of God and His purposes, I'm not convicted that God is referencing you through Isaiah's words.
God bless,
In Christ, ted