Yes, I believe you can. I have seen it happen to two people, but it takes a lot. If you turn from God, He will call you back and He will chastise you when you don't listen (as a good Father), but if you keep resisting Him, rejecting Him, He will eventually let you go. Because He isn't going to force you to be in a relationship with Him or to come to Heaven. In the same way, if you wilfully live in sin, not caring what God thinks, rebelling without a guilty consience, and persist in it despite rebuke, He will eventually turn you over to a reprobate mind. But as I said, it takes a lot. I have seen both happen, and they both lived disastrous, unrepentant lives without guilt, both resisting every time God called them back. One of them blasphemed God and Jesus and everything that is holy and even committed the unforgivable sin many, many times.
A repentant child of God cannot lose their salvation, no matter how much they stumble, because God keeps them safe and cleans them up. I know I couldn't lose my salvation. Technically I could, but not realistically, because when I have stumbled and fallen, God has brought me back to Him. The difference is that I choose to rely on Him and I choose to let Him work in me and I choose to have faith, not resisting Him. I couldn't possibly resist Him, and especially not after having seen what happened to those two people.
This is when people return to their old way of living.
2 Peter 2:17-22 NLT
These people are as useless as dried-up springs or as mist blown away by the wind. They are doomed to blackest darkness. [18] They brag about themselves with empty, foolish boasting. With an appeal to twisted sexual desires, they lure back into sin those who have barely escaped from a lifestyle of deception. [19] They promise freedom, but they themselves are slaves of sin and corruption. For you are a slave to whatever controls you. [20] And when people escape from the wickedness of the world by knowing our Lord and Savior Jesus Christ and then get tangled up and enslaved by sin again, they are worse off than before. [21] It would be better if they had never known the way to righteousness than to know it and then reject the command they were given to live a holy life. [22] They prove the truth of this proverb: “A dog returns to its vomit.” And another says, “A washed pig returns to the mud.”
This is discipline to turn back to God.
1 Corinthians 5:1-5 NLT
I can hardly believe the report about the sexual immorality going on among you—something that even pagans don’t do. I am told that a man in your church is living in sin with his stepmother. [2] You are so proud of yourselves, but you should be mourning in sorrow and shame. And you should remove this man from your fellowship. [3] Even though I am not with you in person, I am with you in the Spirit. And as though I were there, I have already passed judgment on this man [4] in the name of the Lord Jesus. You must call a meeting of the church. I will be present with you in spirit, and so will the power of our Lord Jesus. [5] Then you must throw this man out and hand him over to Satan so that his sinful nature will be destroyed and he himself will be saved on the day the Lord returns.
Does the Message take root?
Matthew 13:18-23 NLT
“Now listen to the explanation of the parable about the farmer planting seeds: [19] The seed that fell on the footpath represents those who hear the message about the Kingdom and don’t understand it. Then the evil one comes and snatches away the seed that was planted in their hearts. [20] The seed on the rocky soil represents those who hear the message and immediately receive it with joy. [21] But since they don’t have deep roots, they don’t last long. They fall away as soon as they have problems or are persecuted for believing God’s word. [22] The seed that fell among the thorns represents those who hear God’s word, but all too quickly the message is crowded out by the worries of this life and the lure of wealth, so no fruit is produced. [23] The seed that fell on good soil represents those who truly hear and understand God’s word and produce a harvest of thirty, sixty, or even a hundred times as much as had been planted!”
Suffering purifies us and produces Fruit in us.
1 Peter 1:3-7 NLT
All praise to God, the Father of our Lord Jesus Christ. It is by his great mercy that we have been born again, because God raised Jesus Christ from the dead. Now we live with great expectation, [4] and we have a priceless inheritance—an inheritance that is kept in heaven for you, pure and undefiled, beyond the reach of change and decay. [5] And through your faith, God is protecting you by his power until you receive this salvation, which is ready to be revealed on the last day for all to see. [6] So be truly glad. There is wonderful joy ahead, even though you must endure many trials for a little while. [7] These trials will show that your faith is genuine. It is being tested as fire tests and purifies gold— though your faith is far more precious than mere gold. So when your faith remains strong through many trials, it will bring you much praise and glory and honor on the day when Jesus Christ is revealed to the whole world.
Either Filled with Good or evil.
Luke 11:20-32 NLT
But if I am casting out demons by the power of God, then the Kingdom of God has arrived among you. [21] For when a strong man is fully armed and guards his palace, his possessions are safe— [22] until someone even stronger attacks and overpowers him, strips him of his weapons, and carries off his belongings. [23] “Anyone who isn’t with me opposes me, and anyone who isn’t working with me is actually working against me. [24] “When an evil spirit leaves a person, it goes into the desert, searching for rest. But when it finds none, it says, ‘I will return to the person I came from.’ [25] So it returns and finds that its former home is all swept and in order. [26] Then the spirit finds seven other spirits more evil than itself, and they all enter the person and live there. And so that person is worse off than before.” [27] As he was speaking, a woman in the crowd called out, “God bless your mother—the womb from which you came, and the breasts that nursed you!” [28] Jesus replied, “But even more blessed are all who hear the word of God and put it into practice.” [29] As the crowd pressed in on Jesus, he said, “This evil generation keeps asking me to show them a miraculous sign. But the only sign I will give them is the sign of Jonah. [30] What happened to him was a sign to the people of Nineveh that God had sent him. What happens to the Son of Man will be a sign to these people that he was sent by God. [31] “The queen of Sheba will stand up against this generation on judgment day and condemn it, for she came from a distant land to hear the wisdom of Solomon. Now someone greater than Solomon is here—but you refuse to listen. [32] The people of Nineveh will also stand up against this generation on judgment day and condemn it, for they repented of their sins at the preaching of Jonah. Now someone greater than Jonah is here—but you refuse to repent.
Matthew 12:38-50 NLT
One day some teachers of religious law and Pharisees came to Jesus and said, “Teacher, we want you to show us a miraculous sign to prove your authority.” [39] But Jesus replied, “Only an evil, adulterous generation would demand a miraculous sign; but the only sign I will give them is the sign of the prophet Jonah. [40] For as Jonah was in the belly of the great fish for three days and three nights, so will the Son of Man be in the heart of the earth for three days and three nights. [41] “The people of Nineveh will stand up against this generation on judgment day and condemn it, for they repented of their sins at the preaching of Jonah. Now someone greater than Jonah is here—but you refuse to repent. [42] The queen of Sheba will also stand up against this generation on judgment day and condemn it, for she came from a distant land to hear the wisdom of Solomon. Now someone greater than Solomon is here—but you refuse to listen. [43] “When an evil spirit leaves a person, it goes into the desert, seeking rest but finding none. [44] Then it says, ‘I will return to the person I came from.’ So it returns and finds its former home empty, swept, and in order. [45] Then the spirit finds seven other spirits more evil than itself, and they all enter the person and live there. And so that person is worse off than before. That will be the experience of this evil generation.” [46] As Jesus was speaking to the crowd, his mother and brothers stood outside, asking to speak to him. [47] Someone told Jesus, “Your mother and your brothers are standing outside, and they want to speak to you.” [48] Jesus asked, “Who is my mother? Who are my brothers?” [49] Then he pointed to his disciples and said, “Look, these are my mother and brothers. [50] Anyone who does the will of my Father in heaven is my brother and sister and mother!”