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Old 2nd September 2009, 01:00 PM
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An open reply to Mark Kennedy

I just hope this gets a response that does not involve a bunch of whiners running to the mods for some trumped up reasons....



Originally Posted by mark kennedy View Post
Hi Professor, good to see you again
Yeah - just like old times. In fact, it is EXACTLY like old times - I see the exact same claims, even the exact same data being used (inappropriately, in most cases)
If I compare two sequences of DNA 100 bases long and 99 of the nucleotides are identical, it is a lie to claim that the DNA sequences I am looking at are 99% identical?
Really, I think the statement is crystal clear in this statement in Scientific American, just as it was in Time and the Nature Web Focus page. Here is the quote again:
A humbling truth ... (Scientific Amercian, What makes us human? by Katherine S. Pollard)
My mistake - I thought you were referring to your same-old, same-old quotes of yore and I did not read this entire thread.
I'm not sure what she is talking about.
Reading the actual paper, I think LifeToTheFullest is onto something - the paper is referring to a collection HARs and it seems to be in reference just to those when compared to chimp, but it is not clear and the SciAm article is clearly either a mistatement or an error.

So I guess all evolutionary biologists mjust be dishonest conspirators...

So you want to condemn all evolutionary biologists on the basis of what one person said in one article?
Can I use that criterion to condemn all Christians because I've seen a few celebrating the assassination of George Tiller?
I've seen creationists claim that no speciation has ever occurred. Does that mean that all creationists believe that ALL extant species were on the ark that didn't really exist anyway?
You know as well as I that it's at least 35 million based on single base differences genome wide and another 90 million bases (45 MB human, 42 MB chimp) based on indels. No where in the article does this capable and accomplished biostatistician indicate that at least since 2005 the known divergence is at least 100 million base pairs larger.
I also know that the number of bases in an indel has nothing to do with the overall mutation rate. What of it?
If I am looking at 2 DNA sequences 100 bases long from two specimens whose genomes are 1 billion bases long and there is 99% identity in the 100 base sequence that I am looking at, is it a lie to claim that 'the DNA' is 99% the same?
The statement is 3 billion base pairs of the human genome diverge by 15 million base pairs. This is simply wrong. Why does a Biology Professor let a statement like this stand when it is clearly erroneous?
What do you mean, 'let it stand'? What would you have me do? Write SciAm and complain that someone said something wrong in an article and that the erroneous statement is really irrelevant to the overall gist fo the article?
The precise number is really not that important, frankly. You are just hung up on it as a means of making what you think is a good argument. It isn't.
What you are saying is that you think that:
-all of the nucleotides involved in insertions deletions and duplications must be accounted for by the overall mutation rate
I think that would be nice but unlikely since the mainstream academic and media sources are not honest about the actual level of divergence.
And creationist detractors are not honest - or very well informed - when it comes to technical issues like this.
It has been explained to you proably a hundred times that the size of an indel is IRRELEVANT because it is a one-time mutational event. It counts as ONE, even if the indel is 10,000 bp long. It all gets inserted or removed in one shot. Therefore, they do not need to be included in the overall mutation rate, which is a measure of the OCCURRENCE of mutation. In fact, doing so would be an exercise in incompetence, sort of like claiming that if we launch a new rocket and it travels 1000 miles, we have to count it as 1000 individual launches because the old rocket could only go 1 mile.
-the largest % difference number, whatever it is based on, is the number to go by
No sir, the actual divergence. The total number of base pairs in the respective genomes that actually are different. Total base pairs/base pairs different would be the accurate ratio translated into a percentage.
As indicated, the actual divergence is largely irrelevant since it would be comparing apples and oranges.
-this larger number must mean that common descent is impossible
I have never said it's impossible, I am saying the the overall divergence indicates accelerated evolution.
But it doesn't necessarily, as has also been explained to you repeatedly. And even if it did, what of it?
When you look at a gene like the HAR 1 gene we are talking about highly accelerated divergence in a highly conserved regulatory gene involved in the early development of cerebral cortex.
Sometimes this happens. Sometimes it doesn't. You seem to require a uniform distribution of mutations at all loci for all time. Nature doesn't work that way, and I've seen your recycled quotes before. Not interested. Did you read the actual scientific pub, or just the SciAm bit? The actual article contains interesting information - such as most of the HARs are found close to the ends of chromosomal arms, indicating a positional effect. Hmmm....
I'm not saying this is impossible, as skeptical as I am I realize there are a lot of things that can change in relatively short spaces of time. I'm saying that this leaves room for honest skepticism Professor and reasonable questions arise and should be addressed.
Sure, asking questions is fine. But presenting questions as if they are evidence for something is quite another thing.
The thing is, if they are not honest about the actual divergence it becomes a credibility issue with me.
You keep tossing the term 'honest' around - do you think it is honest to repeat the same claims year after year when you have had your errors explained to you repeatedly?
- applying the same standards to things like intraspecies comparisons and interspecies comparisons dealing with any species but human and chimp is irrelevant.
I would happily compare them to interspecies and intraspecies comparisons ...
I think the term you are looking for is converged.

You did not understand my statement - your desire to use total raw sequence differences as the yardstick by which to judge hypotheses of descent runs into trouble if we apply the same criteria to other inter- and intraspecies comparisons. So, if we say that we must include all the nucleotides in indels in the raw count, and the human-chimp divergence goes up to 5%, then we have to use the same criterion when comparing dogs to foxes and loggerhead turtles to leatherbacks and even when comparing two individuals of the same species and guess what - the divergence goes up in ALL those cases.
I'm not entirely sure I understood the point you were trying to make here but I assure you my interest in purely academic. As long as evolutionists are honest and straightforward I will accept and even respect their conclusions regarding common ancestry.
History tells me otherwise, especially when you STILL refuse to acknowledge that overall mutation rates do not and should not be required to accommodate indels..

However, as long as the actual evidence is being skewed and the actual divergence is being misrepresented I remain skeptical both of their conclusions and professional integrity as I feel you should be.
Whatever...
Your reading of the literature at one time told you that DNA is made of amino acids and that mutations were "monstrosities." Your reading comprehension - as demonstrated by your history - is nothing to boast of or be confident in.
I know the difference between an amino acid sequence in a protein coding gene and other segments.
There is no amino acid sequence in a gene, protein coding or otherwise.
I have often pointed out that changes in amino acid sequences are neutral at best and when they have an effect they are most often deleterious.
And nobody would disagree. If adaptive evolution were easy, we'd all be supermen.
I wouldn't be as tenacious in my skepticism if you were as zealous to correct errors made by your cohorts and peers.
First, we like to make sure that the claimed errors really were. Second, correcting a claim made by someone on a discussion forum is easy, it can be done in almost real time. Correcting an error made by someone in a national publication is a bit different. Considering the fact that those in the know, know that science is a tentative buisiness, especially on the details, that one researcher claims a 99% identity and another claims 98% and another claims 95%, I don't think it really matters. The fact is that humans and chimps share a greater identity in the overall genomic as well as the genic level than chimps share with the other apes. If we want to make the divergence dependant upon the raw nucleotide difference, then the divergence between chimps and gorillas increases probably by just as much as the human-chimp divergence does.

IOW, your argument is irrelevant.
Depends on what you are comparing. Sorry.
See the above quote, it's whole genome comparisons. [/quote] Other such comparions do not bear it out. No biggie. Hard to tell what Pollard meant. If she DID indeed mean whole genomoe comparisons, then she is wrong. If she was referring to HAR regions, then the statement was clearly either terribly edited or was simply misstated.
It is ~99% generally when comparing homologous genes.
That was not what she said. [/quote] That is what I said.
That is not a lie.
Then what is it? Incompetence? [/quote] Perhaps an error of perspective? You are very quick to ascribe dishonesty when the answer is quite likley something else altogether. I've not read the article - I don't read popular press science magazines for a number of reasons - and I don't really care to. That one person's statement in one article seems incorrect is really quite irrelevant in the broader scheme of things.
When you toss in noncoding DNA and duplicates and the like, the difference increases.
Of course they do.
Good.
Just as it would when comparing ANY two species.
Just as it would when comparing any two humans.
Why you seem to think this is so significant in terms of the human-chimp question can be answered by realizing that your religious fervor dictates a need to be correct on a seperate ancestry for apes and humans.
My religion is a separate issue
Funny then that the only people that do not seem to accept it are religious.
the issue here is that a glaring error is being dismissed and rationalized.
And therefore.... what? I shan't get my panties in a bunch over what someone wrote in a popular press magazine.
No need to engage in your ego stroking 'challenges' to 1 on 1 debates - you never write anything in them that you don't write in the regular forum and you employ the exact same dodges and antics.
I know you have no interest in a real debate and I can't say I blame you since the evidence is actually pretty difficult to reconcile to you cherished assumptions.
Real debate is fine. Manefactured, recycled nonsense for the purposes of ego stroking is not. The last time I was in an 'official' debate on a discussion forum, my opponant ran away from the agreed upon topic in his first response, and insisted that he won because I would not diverge from the agreed upon topic.
I have no cherished assumptions to reconcile, whatever that is supposed to mean. You cannot simply ignore evidence because a person makes an error in a popular press article.
You are wrong here and you are wrong in 1 on 1 debates. The venue is immaterial.
If I'm so wrong then why does the statement made by Pollard contradict the finding of the Chimpanzee Genome Consortium published in 2005? You don't like to talk about that and yet you are unable to convince anyone, even yourself, that I am the one in error.
I'm not talking about your fixation on what someone says in pop press articles, I am talking about your basic positions - indels in mutation rates, brain grows too fast, etc.
You want to accuse me of error? Let's do it this way...You know it's not 99% yet you won't admit it.
Ummm....

I've written repeatedly that it is not 99%. Not the overall identity, anyway. I KNOW that it is not 99% overall. I also know that there are very sound reasons NOT to use the higher numbers as espoused by Britten when looking at descent, because in such cases the total divergence is misleading.
I also know that when comparing coding genes, the number is quite high, 99.4% reported in a recent study. Recent studies have also shown that any 2 humans diverge by about 10 times the amount previously thought. Are you going to be similarly fixated when spomeone writes that humans are 99.9% identical genetically?
I am neither surprised nor remotely impressed with the rationalizations you are making here. You would never tolerate such a glaring error made by a creationist but you ignore it when it's made in popular press. Shame on you Professor! I would expect better from a professional Biologist.

Thanks for the jousting match that reinforces my distrust of the academic and intellectual community with regards to our origins. To agree with such a blatant error is to abandon all intellectual integrity. Now you can either correct the error in the statement in the OP and the one in Scientific American or you can stop with the pretense of my errors conflating the actual evidence. My experience with evolutionists has been that you will do neither.
I am not surprised or impressed by the fact that you are fixating on something as irrelevant as this. Nor am I impressed or surprised that despite 5 years of having your erroneous genetics claims explained to you, you are still proudly making them.
The fact of the matter is that Pollard's claim is really irrelevant in the overall scheme of things. That your are fixated on it is demonstrative of the minutiae with which anti-evolutionists confine themselves, for the big issues are too much for them to handle.
Pollard's error has no bearing whatsoever on the evidence for descent, and a person that thinks it does is living in a fantasy land.
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  #2  
Old 2nd September 2009, 04:13 PM
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Kiss

Originally Posted by SLP View Post
I just hope this gets a response that does not involve a bunch of whiners running to the mods for some trumped up reasons....
First of all I would like nothing better then to answer your statements but currently I am deployed to Afghanistan and I'm stationed at at outpost type place (it's called a FOB actually). We get internet but it's slower then the wheels of justice and I only get about a half an hour.

Any way, I will be glad to respond when I get the chance and since you saw fit to post it to my visitors message center rather then dropping it in a PM I suppose I'll have it forever. I'll get to it first realistic chance I get...by the way...the 99% the same propaganda has always smelled fishy to me. What has really burnt me up is that you guys are so all fired happy to point out creationists mistakes but won't admit them from your own.

I'll get to the thread in time and as far as what the moderators might think of your posts, if they close this one I'll start another one. Still think it's sad you won't have a formal debate with me on the topic but I guess when you are applauded in the Darwinian theater of the mind it's hard to get away from your support system.

Take care of yourself Professor, hope to have the chance to discuss this further in the near future.

Grace and peace,
Mark
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Old 2nd September 2009, 05:45 PM
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Old 2nd September 2009, 06:32 PM
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Originally Posted by mark kennedy View Post
First of all I would like nothing better then to answer your statements but currently I am deployed to Afghanistan and I'm stationed at at outpost type place (it's called a FOB actually). We get internet but it's slower then the wheels of justice and I only get about a half an hour.

Any way, I will be glad to respond when I get the chance and since you saw fit to post it to my visitors message center rather then dropping it in a PM I suppose I'll have it forever. I'll get to it first realistic chance I get...by the way...the 99% the same propaganda has always smelled fishy to me. What has really burnt me up is that you guys are so all fired happy to point out creationists mistakes but won't admit them from your own.

I'll get to the thread in time and as far as what the moderators might think of your posts, if they close this one I'll start another one. Still think it's sad you won't have a formal debate with me on the topic but I guess when you are applauded in the Darwinian theater of the mind it's hard to get away from your support system.

Take care of yourself Professor, hope to have the chance to discuss this further in the near future.

Grace and peace,
Mark
Godspeed and stay safe Mark.
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Old 3rd September 2009, 10:31 AM
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Old 4th September 2009, 01:13 PM
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so, no real response, as predicted

Originally Posted by mark kennedy View Post
First of all I would like nothing better then to answer your statements but currently I am deployed to Afghanistan and I'm stationed at at outpost type place (it's called a FOB actually). We get internet but it's slower then the wheels of justice and I only get about a half an hour.
And yet you have had MONTHS to answer it before....
...the 99% the same propaganda has always smelled fishy to me. What has really burnt me up is that you guys are so all fired happy to point out creationists mistakes but won't admit them from your own.
So I guess you ignored my reply again.

Not surprised.

Unfortuantely, you have this odd inability to understand context. The 99% thing is CORRECT in some contexts, but not in others. You, however, always demand that the number be applied in one particular context.
Why is that?

Still think it's sad you won't have a formal debate with me on the topic but I guess when you are applauded in the Darwinian theater of the mind it's hard to get away from your support system.
I've explained more than once why I wil not do that.

Since you don't seem to remember:

1. Because the last time I was in a 'formal' debate with a creationist the creationist tried to change the agreed upon topic in his very first reply, then claimed victory because I would not discuss his 'new' subject

2. I've seen your 'formal' debates on this and similar topics before. No material is brought up in them that is not brought up in public forums. If I can ignore the YEC cheerleaders who never contribute anythign of substance in the public threads, so can you.

3. Engaging in such 'formal' debates is used by creationists as a badge of honor (ego boosting). They get to claim that they 'took on' a real life scientist - which is a victory of sorts from the outset, and then they get to claim victory, regardless of the outcome, and will have a ready-made group of acolytes to trumpet this 'victory' in the guise of YEC forum participants.

4. You keep regurgitating the exact same claims over and over. You seem immune to being reasoned with, immune to acknowledging your errors, immune from realizing that your arguments are misplaced, displaced, or just plain sily.

Here or nowhere.

Last edited by SLP; 4th September 2009 at 01:19 PM.
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  #7  
Old 5th September 2009, 07:03 AM
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Originally Posted by Tinker Grey View Post
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Old 5th September 2009, 07:04 AM
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Originally Posted by Hisbygrace View Post
God bless Mark and thank you soo much for all you are doing for us folks back home!
Thank you, your very kind.
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Old 5th September 2009, 07:51 AM
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The Theory of Evolution is really not that complicated. We observe that alleles change over time through observed mechanisms such as genetic mutations, natural selection, sexual selection, speciation. We can also observe the history of evolution in the fossil record in an unbroken nested hierarchy. There is no reason not to accept the Theory of Evolution when this is understood.
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Old 5th September 2009, 08:59 AM
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Originally Posted by SLP View Post
I just hope this gets a response that does not involve a bunch of whiners running to the mods for some trumped up reasons...
You mean people who get tired of your constant flames.

Yeah - just like old times. In fact, it is EXACTLY like old times - I see the exact same claims, even the exact same data being used (inappropriately, in most cases)
Yep, most of it is rehash since I long ago abandoned the hope that evolutionists would debate the topic on the evidence. It never ceases to amaze me that you scoff and mock at every statement and yet manage to find the time to have a discussion with someone who hold a view you deeply and venomously hate. I sometimes wonder what you get out of these discussions because you obviously could care less about persuasion.

My mistake - I thought you were referring to your same-old, same-old quotes of yore and I did not read this entire thread.
We have been through this, the Chimpanzee Genome project found that we are something like 95% the same in our DNA. It wouldn't be such a big deal if people like you were not pushing the myth that we are so alike physically and genetically we must be related by lineage and belong in the same genus.

I'm not sure what she is talking about.
Reading the actual paper, I think LifeToTheFullest is onto something - the paper is referring to a collection HARs and it seems to be in reference just to those when compared to chimp, but it is not clear and the SciAm article is clearly either a mistatement or an error.
It's just plain wrong.

So I guess all evolutionary biologists mjust be dishonest conspirators...
Not in the peer reviewed literature, they'll get it right there.

So you want to condemn all evolutionary biologists on the basis of what one person said in one article?
This woman is someone I respect and admire, I'm saying the statement is bogus, nothing more. This is not about her, it's about the likes of you pretending to care about science when all you really want to do is mock a religion you know nothing about.

Can I use that criterion to condemn all Christians because I've seen a few celebrating the assassination of George Tiller?
I've seen creationists claim that no speciation has ever occurred. Does that mean that all creationists believe that ALL extant species were on the ark that didn't really exist anyway?
I do hope you realize that most creationists would have nothing to do with these discussions.

I also know that the number of bases in an indel has nothing to do with the overall mutation rate. What of it?
The web focus article announcing the publication of the Initial Sequence of the Chimpanzee Genome said:
What makes us human? We share more than 98% of our DNA and almost all of our genes with our closest living relative, the chimpanzee Chimpanzee Genome
This will be at the top of the list when you type Chimpanzee Genome into the Google search engine. The paper says something like 1.4% from single base substitutions but indels are:
On the basis of this analysis, we estimate that the human and chimpanzee genomes each contain 40–45 Mb of species-specific euchromatic sequence, and the indel differences between the genomes thus total 90 Mb. This difference corresponds to 3% of both genomes and dwarfs the 1.23% difference resulting from nucleotide substitutions; this confirms and extends several recent studies (Initial sequence of the chimpanzee genome and comparison with the human genome)
How do you explain that Professor? Time magazine did the exact same thing, they expressly cite the Chimpanzee Genome paper saying that it says we are 99% the same as Chimpanzees. I wrote Time and of course they ignored it.

What do you mean, 'let it stand'? What would you have me do? Write SciAm and complain that someone said something wrong in an article and that the erroneous statement is really irrelevant to the overall gist fo the article?
The precise number is really not that important, frankly. You are just hung up on it as a means of making what you think is a good argument. It isn't
.

That statement is typical of the propaganda evolutionists are putting out. When I keep seeing the same half backed statistics and generalities knowing what the actual facts are it makes them (including you) look increasingly desperate. Put the facts on the table and let the truth stand or fall on it's own merit. A year or so after the Chimpanzee article I started seeing research into human DNA comparisons. Guess what, we can diverge by more then 1% but that does not get to be a point when you let a statement like this stand. Then you either have to back peddle and explain the errors or suffer the loss of confidence and credibility.

And creationist detractors are not honest - or very well informed - when it comes to technical issues like this.
That is why I like to stay on the simplest, most obvious and undeniable point I know of. We are not 99% the same as Chimpanzees in our DNA but you guys have no problem with Pollard, Time or Nature Web Focus saying we are. You will exaggerate and magnify any error creationists make but not this one, you will pretend I'm not as enlightened as you. The fact is you are frustrated that you can't get everyone to make the a priori assumption of universal common descent and be done with God as Creator forever.

It has been explained to you proably a hundred times that the size of an indel is IRRELEVANT because it is a one-time mutational event. It counts as ONE, even if the indel is 10,000 bp long. It all gets inserted or removed in one shot. Therefore, they do not need to be included in the overall mutation
rate, which is a measure of the OCCURRENCE of mutation. In fact, doing so would be an exercise in incompetence, sort of like claiming that if we launch a new rocket and it travels 1000 miles, we have to count it as 1000 individual launches because the old rocket could only go 1 mile.
You keep explaining that as if I didn't understand that in the first place. You like to break it down to kindergarden level but the fact is that the differences between 99% and 95% involves hundreds of millions of base pairs. Let's do this again just for fun:

5 million years ago lived the common ancestor
35 million single base substitutions
5 million indels adding up to about 90 million base pairs

Thats one indel, permanently fixed per year for 5 million years and 7 single base substitutions. Given a generation of 20 years you have 20 indels and 140 single base substitutions. Mind you these do not include the 9 major chromosomal rearrangements that range from 2 Mb to 10 Mb.

Your right though, it really doesn't matter so why not use the right numbers instead of exaggerating the similarity? Could it be because you like these homology arguments so much you just can't help but hoard them even when they are obviously false.

As indicated, the actual divergence is largely irrelevant since it would be comparing apples and oranges
.

Nonsense, it would be comparing two species thought to be related by lineage. The further apart they are genetically the less likely they are to be related. What's the matter Professor, can't handle the inverse logic when it contradicts you forgone conclusions?

But it doesn't necessarily, as has also been explained to you repeatedly. And even if it did, what of it?
That regulatory gene HAR1f was virtually unchanged for over 300 million years allowing only 2 substitutions. Then for the human lineage to emerge there had to be 18 substitutions about 2 million years ago when the expansion of the cerebral cortex began to grow exponentially. Add to that the fact that every ape fossil they dig up in Africa is automatically classified as hominid which is why there are hundreds of hominid fossils and none of them are classified as chimpanzee ancestors.

It is pure, undiluted duplicity.

Sometimes this happens. Sometimes it doesn't. You seem to require a uniform distribution of mutations at all loci for all time. Nature doesn't work that way, and I've seen your recycled quotes before. Not interested. Did you read the actual scientific pub, or just the SciAm bit? The actual article contains interesting information - such as most of the HARs are found close to the ends of chromosomal arms, indicating a positional effect. Hmmm....
Yes the article does touch on that and she has a couple of other papers that discuss brain related gene comparisons. The point is that this kind of homology argument is just plain wrong. Why don't you write SciAm or Pollard why she said 99% when all the latest research is indicating no more then 96% the same in our DNA? My guess its because you already know.

Sure, asking questions is fine. But presenting questions as if they are evidence for something is quite another thing
.

The problem is that you guys like to exaggerate errors and beat creationists over the head with them. Why is it so hard to admit this one? There are an abundance of genes that show accelerated evolution but the mention of actual mechanisms for making an adaptive evolutionary change never seems to enter the conversation. The problem is that it's assumed rather then proven and the evidence is organized around the assumption.

You keep tossing the term 'honest' around - do you think it is honest to repeat the same claims year after year when you have had your errors explained to you repeatedly?
It's not honest and the error of the statement in SciAm is obvious and yet you do not explain it, correct it or have the slightest problem with it simply because it was not made by a creationist. I emphasis the single most obvious and inescapable error or misinformation statement I can find. We discussed mutation rates and you guys just derailed the discussion. We talked about the three-fold expansion of the human brain from that of apes and the requisite genes involved and you guys derailed the discussion. I have discussed these bogus homology arguments from things like ERVs and watch them crumble into dust and ashes.

Why don't you address this error? Which is it Professor, 99% or 96% the same in our DNA?

I think the term you are looking for is converged.
Perhaps

You did not understand my statement - your desire to use total raw sequence differences as the yardstick by which to judge hypotheses of descent runs into trouble if we apply the same criteria to other inter- and intraspecies comparisons. So, if we say that we must include all the nucleotides in indels in the raw count, and the human-chimp divergence goes up to 5%, then we have to use the same criterion when comparing dogs to foxes and loggerhead turtles to leatherbacks and even when comparing two individuals of the same species and guess what - the divergence goes up in ALL those cases.
No sir, what I really want is a directly observed or demonstrated mechanism for the three-fold expansion of the human brain from that of apes. Random mutations with some serendipitous beneficial effects simply have no way of accomplishing this. I honestly would have to difficulty reconciling my religious convictions to a totally naturalistic evolutionary pathway except that I will not have this a priori assumption forced upon me by the Scientific or Academic elitists.
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“Gärtner, by the results of these transformation experiments, was led to oppose the opinion of those naturalists who dispute the stability of plant species and believe in a continuous evolution of vegetation. He perceives in the complete transformation of one species into another an indubitable proof that species are fixed with limits beyond which they cannot change.” (G. Mendel)
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