That's not Heisenberg's uncertainty principle is it?
No, that's only electrons. Microstates is more like... say you have two atoms. At 300K, they each vibrate, say, (pulls a random number out of thin air) 30 nm from where they would at absolute zero, in 1 nm increments. So they can both be anywhere from -15 to 0 to +15 nm from their absolute zero point. For the two atom system, then, there's then 30*30 microstates. But if we cut the temp by 10%, and instead of 30*30 microstates, there is now 27*27 microstates, because they don't vibrate as much due to the lower temp, you've lost information about the system.
Remember, I did just pull all the numbers out of thin air to show what I meant, none of the numbers represent an actual situation.
Metherion